In vivo glia‐to‐neuron conversion: pitfalls and solutions
Sign Up to like & getrecommendations! Published in 2022 at "Developmental Neurobiology"
DOI: 10.1002/dneu.22880
Abstract: Neuron loss and disruption of neural circuits are associated with many neurological conditions. A key question is how to rebuild neural circuits for functional improvements. In vivo glia‐to‐neuron (GtN) conversion emerges as a potential solution… read more here.
Keywords: glia neuron; conversion pitfalls; neuron conversion; vivo glia ... See more keywords
Transcriptomic analyses of NeuroD1‐mediated astrocyte‐to‐neuron conversion
Sign Up to like & getrecommendations! Published in 2022 at "Developmental Neurobiology"
DOI: 10.1002/dneu.22882
Abstract: Ectopic expression of a single neural transcription factor NeuroD1 can reprogram reactive glial cells into functional neurons both in vitro and in vivo, but the underlying mechanisms are not well understood yet. Here, we used… read more here.
Keywords: neurod1 mediated; neuron conversion; conversion; astrocyte neuron ... See more keywords
Regeneration of Functional Neurons After Spinal Cord Injury via in situ NeuroD1-Mediated Astrocyte-to-Neuron Conversion
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2020.591883
Abstract: Spinal cord injury (SCI) often leads to impaired motor and sensory functions, partially because the injury-induced neuronal loss cannot be easily replenished through endogenous mechanisms. In vivo neuronal reprogramming has emerged as a novel technology… read more here.
Keywords: neuron conversion; astrocyte neuron; regeneration; conversion ... See more keywords