Intracerebroventricular Delivery in Mice for Motor Neuron Diseases.
Sign Up to like & getrecommendations! Published in 2017 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-6817-6_19
Abstract: The use of antisense oligonucleotides to target specific mRNA sequences represents a promising therapeutic strategy for neurological disorders. Recent advances in antisense technology enclose the development of phosphorodiamidate morpholino oligomers (MO), which is one of… read more here.
Keywords: neuron diseases; delivery; motor neuron; mice ... See more keywords
Autophagy in motor neuron diseases.
Sign Up to like & getrecommendations! Published in 2020 at "Progress in molecular biology and translational science"
DOI: 10.1016/bs.pmbts.2020.03.009
Abstract: Motor neuron diseases (MNDs) are a wide group of neurodegenerative disorders characterized by the degeneration of a specific neuronal type located in the central nervous system, the motor neuron (MN). There are two main types… read more here.
Keywords: autophagy motor; motor neuron; neuron diseases; motor ... See more keywords
1,2-Dehydropyrrolizidine Alkaloids: Their Potential as a Dietary Cause of Sporadic Motor Neuron Diseases.
Sign Up to like & getrecommendations! Published in 2022 at "Chemical research in toxicology"
DOI: 10.1021/acs.chemrestox.1c00384
Abstract: Sporadic motor neuron diseases (MNDs), such as amyotrophic lateral sclerosis (ALS), can be caused by spontaneous genetic mutations. However, many sporadic cases of ALS and other debilitating neurodegenerative diseases (NDDs) are believed to be caused… read more here.
Keywords: sporadic motor; motor neuron; motor; pathology ... See more keywords
Commissural fiber degeneration in motor neuron diseases
Sign Up to like & getrecommendations! Published in 2020 at "Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration"
DOI: 10.1080/21678421.2020.1752253
Abstract: Corpus callosum degeneration is a recognized feature of amyotrophic lateral sclerosis; it has been consistently highlighted by post mortem studies and repeatedly demonstrated in vivo by computation... read more here.
Keywords: commissural fiber; motor neuron; degeneration motor; neuron diseases ... See more keywords
Progression of cognitive and behavioral disturbances in motor neuron diseases assessed using standard and computer-based batteries
Sign Up to like & getrecommendations! Published in 2021 at "Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration"
DOI: 10.1080/21678421.2020.1867179
Abstract: Abstract Objective: Detecting and monitoring cognitive and behavioral deficits in motor neuron diseases (MND) is critical due to their considerable clinical impact. In this scenario, computer-based batteries may play an important role. In this study,… read more here.
Keywords: cognitive behavioral; computer based; motor neuron; neuron diseases ... See more keywords
Exploring Motor Neuron Diseases Using iPSC Platforms.
Sign Up to like & getrecommendations! Published in 2022 at "Stem cells"
DOI: 10.1093/stmcls/sxab006
Abstract: The degeneration of motor neurons is a pathological hallmark of motor neuron diseases (MNDs), but emerging evidence suggests that neuronal vulnerability extends well beyond this cell subtype. The ability to assess motor function in the… read more here.
Keywords: exploring motor; neuron diseases; diseases using; motor ... See more keywords
New trends in treatment of muscle fatigue throughout rehabilitation of elderlies with motor neuron diseases
Sign Up to like & getrecommendations! Published in 2022 at "World Journal of Clinical Cases"
DOI: 10.12998/wjcc.v10.i2.397
Abstract: Muscle fatigue is a problem in rehabilitation, particularly in elderlies and patients with motor neuron diseases. There are high contradictions in the effectiveness of the used methods to decrease muscle fatigue during rehabilitation. They mainly… read more here.
Keywords: muscle; rehabilitation; muscle fatigue; motor neuron ... See more keywords
A Crucial Role for the Protein Quality Control System in Motor Neuron Diseases
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Aging Neuroscience"
DOI: 10.3389/fnagi.2020.00191
Abstract: Motor neuron diseases (MNDs) are fatal diseases characterized by loss of motor neurons in the brain cortex, in the bulbar region, and/or in the anterior horns of the spinal cord. While generally sporadic, inherited forms… read more here.
Keywords: system; motor neuron; neuron diseases; protein quality ... See more keywords
Biological networks and complexity in early-onset motor neuron diseases
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Neurology"
DOI: 10.3389/fneur.2022.1035406
Abstract: Motor neuron diseases (MNDs) are neuromuscular disorders where the spinal motor neurons–either the cell bodies themselves or their axons–are the primary cells affected. To date, there are 120 different genes that are lost or mutated… read more here.
Keywords: neuron diseases; early onset; onset; motor ... See more keywords
ALS2-Related Motor Neuron Diseases: From Symptoms to Molecules
Sign Up to like & getrecommendations! Published in 2022 at "Biology"
DOI: 10.3390/biology11010077
Abstract: Simple Summary Mutations of the ALS2 gene, which encodes for the protein Alsin, are linked to three recessive motor neuron diseases characterized by early onset. Alsin is an intriguing protein characterized by several structured domains… read more here.
Keywords: als2 related; alsin; neuron diseases; motor neuron ... See more keywords
Implications of Artificial Intelligence Algorithms in the Diagnosis and Treatment of Motor Neuron Diseases—A Review
Sign Up to like & getrecommendations! Published in 2023 at "Life"
DOI: 10.3390/life13041031
Abstract: Motor neuron diseases (MNDs) are a group of chronic neurological disorders characterized by the progressive failure of the motor system. Currently, these disorders do not have a definitive treatment; therefore, it is of huge importance… read more here.
Keywords: neuron diseases; artificial intelligence; motor; motor neuron ... See more keywords