Transcriptional Programming of Human Mechanosensory Neuron Subtypes from Pluripotent Stem Cells
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DOI: 10.1016/j.celrep.2019.12.062
Abstract: SUMMARY Efficient and homogeneous in vitro generation of peripheral sensory neurons may provide a framework for novel drug screening platforms and disease models of touch and pain. We discover that, by ovesssrexpressing NGN2 and BRN3A,… read more here.
Keywords: neuron subtypes; neuron; pluripotent stem; stem ... See more keywords
scRNA-Seq Reveals New Enteric Nervous System Roles for GDNF, NRTN, and TBX3
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DOI: 10.1016/j.jcmgh.2020.12.014
Abstract: Background and Aims Bowel function requires coordinated activity of diverse enteric neuron subtypes. Our aim was to define gene expression in these neuron subtypes to facilitate development of novel therapeutic approaches to treat devastating enteric… read more here.
Keywords: seq; neuron subtypes; nervous system; gdnf nrtn ... See more keywords
Cortical neurons exhibit diverse myelination patterns that scale between mouse brain regions and regenerate after demyelination
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DOI: 10.1038/s41467-021-25035-2
Abstract: Axons in the cerebral cortex show a broad range of myelin coverage. Oligodendrocytes establish this pattern by selecting a cohort of axons for myelination; however, the distribution of myelin on distinct neurons and extent of… read more here.
Keywords: demyelination; neuron subtypes; distinct neuron; myelination patterns ... See more keywords