Deubiquitinase CYLD acts as a negative regulator of dopamine neuron survival in Parkinson's disease.
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DOI: 10.1126/sciadv.abh1824
Abstract: Mutations in PINK1 and parkin highlight the mitochondrial axis of Parkinson's disease (PD) pathogenesis. PINK1/parkin regulation of the transcriptional repressor PARIS bears direct relevance to dopamine neuron survival through augmentation of PGC-1α-dependent mitochondrial biogenesis. Notably,… read more here.
Keywords: dopamine neuron; neuron survival; paris;