Neuron-Type Specific Loss of CDKL5 Leads to Alterations in mTOR Signaling and Synaptic Markers
Sign Up to like & getrecommendations! Published in 2018 at "Molecular Neurobiology"
DOI: 10.1007/s12035-018-1346-8
Abstract: CDKL5 disorder is a devastating neurodevelopmental disorder associated with epilepsy, developmental retardation, autism, and related phenotypes. Mutations in the CDKL5 gene, encoding CDKL5, have been identified in this disorder. CDKL5 is a protein with homology… read more here.
Keywords: type specific; neuron type; mtor signaling; loss cdkl5 ... See more keywords
Dissecting executive control circuits with neuron types
Sign Up to like & getrecommendations! Published in 2019 at "Neuroscience Research"
DOI: 10.1016/j.neures.2018.07.004
Abstract: Executive control supports our ability to behave flexibly in accordance with a given situation. In order to fully understand how cortical circuits achieve this task, we need to determine the intrinsic physiological and connection profiles… read more here.
Keywords: dissecting executive; executive control; neuron type; control ... See more keywords
Neuron type classification in rat brain based on integrative convolutional and tree-based recurrent neural networks
Sign Up to like & getrecommendations! Published in 2021 at "Scientific Reports"
DOI: 10.1038/s41598-021-86780-4
Abstract: The study of cellular complexity in the nervous system based on anatomy has shown more practical and objective advantages in morphology than other perspectives on molecular, physiological, and evolutionary aspects. However, morphology-based neuron type classification… read more here.
Keywords: classification; neuron type; tree; type classification ... See more keywords
Joint actions of diverse transcription factor families establish neuron-type identities and promote enhancer selectivity
Sign Up to like & getrecommendations! Published in 2022 at "Genome Research"
DOI: 10.1101/2020.09.04.283036
Abstract: To systematically investigate the complexity of neuron-specification regulatory networks we performed an RNA interference (RNAi) screen against all 875 transcription factors (TFs) encoded in Caenorhabditis elegans genome and searched for defects in nine different neuron… read more here.
Keywords: neuron type; actions diverse; neuron types; transcription ... See more keywords