Neuronal autophagy and axon degeneration
Sign Up to like & getrecommendations! Published in 2018 at "Cellular and Molecular Life Sciences"
DOI: 10.1007/s00018-018-2812-1
Abstract: Axon degeneration is a pathophysiological process of axonal dying and breakdown, which is characterized by several morphological features including the accumulation of axoplasmic organelles, disassembly of microtubules, and fragmentation of the axonal cytoskeleton. Autophagy, a… read more here.
Keywords: autophagy axon; degeneration; axon degeneration; neuronal autophagy ... See more keywords
DRAM Is Involved in Regulating Nucleoside Analog-Induced Neuronal Autophagy in a p53-Independent Manner
Sign Up to like & getrecommendations! Published in 2017 at "Molecular Neurobiology"
DOI: 10.1007/s12035-017-0426-5
Abstract: The widespread use of combined anti-retroviral therapy (cART) has not decreased the prevalence of HIV-1-associated neurocognitive disorder (HAND), a type of neurodegenerative disease, even though cART effectively inhibits virus colonization in the central nervous system.… read more here.
Keywords: induced neuronal; dram involved; autophagy p53; neuronal autophagy ... See more keywords
The progress of neuronal autophagy in cerebral ischemia stroke: Mechanisms, roles and research methods
Sign Up to like & getrecommendations! Published in 2019 at "Journal of the Neurological Sciences"
DOI: 10.1016/j.jns.2019.03.015
Abstract: There is increasing evidence indicating that autophagy may be a new target in the treatment of ischemic stroke. Moderate autophagy can clear damaged organelles, thereby protecting cells against various injuries. However, long-term excessive autophagy brings… read more here.
Keywords: research methods; autophagy cerebral; autophagy; neuronal autophagy ... See more keywords
Role of p75 neurotrophin receptor in neuronal autophagy in intracerebral hemorrhage in rats through the mTOR signaling pathway
Sign Up to like & getrecommendations! Published in 2020 at "Cell Cycle"
DOI: 10.1080/15384101.2019.1711318
Abstract: ABSTRACT Rupture of weakened blood vessels could lead to severe intracerebral hemorrhage (ICH) and brain injuries. This study was designed to explore the roles of p75 neurotrophin receptor (p75NTR) in neuronal autophagy in ICH rats.… read more here.
Keywords: neurotrophin receptor; intracerebral hemorrhage; mtor signaling; brain ... See more keywords
Neuronal autophagy declines substantially with age and is rescued by overexpression of WIPI2
Sign Up to like & getrecommendations! Published in 2019 at "Autophagy"
DOI: 10.1080/15548627.2019.1695401
Abstract: ABSTRACT Macroautophagy/autophagy is implicated in age-dependent neurodegenerative diseases, including amyotrophic lateral sclerosis and Parkinson, Huntington and Alzheimer diseases, suggesting that an age-related decline in neuronal autophagy may contribute to the onset of neurodegeneration. We identified… read more here.
Keywords: autophagy declines; age; declines substantially; autophagy ... See more keywords
Anesthetic Agents and Neuronal Autophagy. What We Know and What We Don't.
Sign Up to like & getrecommendations! Published in 2018 at "Current medicinal chemistry"
DOI: 10.2174/0929867324666171009123605
Abstract: BACKGROUND Ethanol is known to have both γ-Aminobutyric acid agonist and Nmethyl- D-aspartate antagonist characteristics similar to commonly used volatile anesthetic agents. Recent evidence demonstrates that autophagy can reduce the development of ethanol induced neurotoxicity.… read more here.
Keywords: neuronal autophagy; anesthetic agents; autophagy; agents neuronal ... See more keywords
Hyperactive neuronal autophagy depletes BDNF and impairs adult hippocampal neurogenesis in a corticosterone-induced mouse model of depression
Sign Up to like & getrecommendations! Published in 2023 at "Theranostics"
DOI: 10.7150/thno.81067
Abstract: Background: Depression is a mental disorder that poses a serious threat to human health. Adult hippocampal neurogenesis (AHN) is closely associated with the efficacy of antidepressants. Chronic treatment with corticosterone (CORT), a well-validated pharmacological stressor,… read more here.
Keywords: chronic cort; depression; neuronal autophagy; hippocampal neurogenesis ... See more keywords
A phosphoswitch at acinus-serine437 controls autophagic responses to cadmium exposure and neurodegenerative stress
Sign Up to like & getrecommendations! Published in 2022 at "eLife"
DOI: 10.7554/elife.72169
Abstract: Neuronal health depends on quality control functions of autophagy, but mechanisms regulating neuronal autophagy are poorly understood. Previously, we showed that in Drosophila starvation-independent quality control autophagy is regulated by acinus (acn) and the Cdk5-dependent… read more here.
Keywords: acn s437; neuronal autophagy; serine437; acinus serine437 ... See more keywords