TDP-43 transports ribosomal protein mRNA to regulate axonal local translation in neuronal axons
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DOI: 10.1007/s00401-020-02205-y
Abstract: Mislocalization and abnormal deposition of TDP-43 into the cytoplasm (TDP-43 proteinopathy) is a hallmark in neurons of amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD). However, the pathogenic mechanism of the diseases linked to… read more here.
Keywords: neuronal axons; protein; local translation; tdp ... See more keywords