Nanoscale‐tipped wire array injections transfer DNA directly into brain cells ex vivo and in vivo
Sign Up to like & getrecommendations! Published in 2022 at "FEBS Open Bio"
DOI: 10.1002/2211-5463.13377
Abstract: Genetic modification to restore cell functions in the brain can be performed through the delivery of biomolecules in a minimally invasive manner into live neuronal cells within brain tissues. However, conventional nanoscale needles are too… read more here.
Keywords: brain; vivo vivo; neuronal cells; wire ... See more keywords
Glutamic Acid Modified Gold Nanorod Sensor for the Detection of Calcium ions in Neuronal Cells
Sign Up to like & getrecommendations! Published in 2024 at "ChemBioChem"
DOI: 10.1002/cbic.202400009
Abstract: Calcium (Ca2+) ions play a crucial role in the functioning of neurons, governing various aspects of neuronal activity such as rapid modulation and alterations in gene expression. Ca2+ signaling has a significant impact on the… read more here.
Keywords: glutamic acid; calcium; ca2; neuronal cells ... See more keywords
Amyloid Fibril Formation on Neuronal Cells in the Coexistence of Aβ40 and Aβ42
Sign Up to like & getrecommendations! Published in 2024 at "ChemBioChem"
DOI: 10.1002/cbic.202400603
Abstract: The abnormal aggregation and subsequent deposition of amyloid β‐protein (Aβ) in the brain are considered central to the pathogenesis of Alzheimer's disease. The two major species of Aβ are Aβ40 and Aβ42, present at an… read more here.
Keywords: fibril formation; amyloid fibril; formation neuronal; aggregation ... See more keywords
N‐Acety‐L‐Cysteine Alleviates Isoflurane‐Triggered Neuronal Cell Parthanatos by Suppressing Reactive Oxygen Species Accumulation Through the Induction of c‐Jun N‐Terminal Kinase Signaling Pathway Inhibition
Sign Up to like & getrecommendations! Published in 2025 at "Journal of Biochemical and Molecular Toxicology"
DOI: 10.1002/jbt.70268
Abstract: In recent years, the potential neurotoxicity of inhaled anesthetics on the developing brain has increasingly garnered attention, yet its mechanism remains unclear. Parthanatos is a newly discovered form of programmed cell death dependent on PARP‐1,… read more here.
Keywords: ros; isoflurane; oxidative stress; cell ... See more keywords
Higenamine protects neuronal cells from oxygen‐glucose deprivation/reoxygenation‐induced injury
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular Biochemistry"
DOI: 10.1002/jcb.27656
Abstract: Higenamine, a plant‐based alkaloid, exhibits various properties, such as antiapoptotic and antioxidative effects. Previous studies proved that higenamine possesses potential therapeutic effects for ischemia/reperfusion (I/R) injuries. However, the role of higenamine in cerebral I/R injury… read more here.
Keywords: neuronal cells; higenamine; glucose deprivation; higenamine protects ... See more keywords
Expression and Functional Study of Single Mutations of Carbonic Anhydrase 8 in Neuronal Cells
Sign Up to like & getrecommendations! Published in 2020 at "Cellular and Molecular Neurobiology"
DOI: 10.1007/s10571-020-00907-1
Abstract: Carbonic anhydrase 8 (CA8), an isozyme of α-carbonic anhydrases, lacks the ability to catalyze the reversible hydration of CO 2 to bicarbonate and proton. Previous studies have shown that single point mutations of CA8, CA8-S100P,… read more here.
Keywords: neuronal cells; ca8 g162r; s100p ca8; ca8 s100p ... See more keywords
Cadmium Impairs Autophagy Leading to Apoptosis by Ca2+-Dependent Activation of JNK Signaling Pathway in Neuronal Cells.
Sign Up to like & getrecommendations! Published in 2021 at "Neurochemical research"
DOI: 10.1007/s11064-021-03341-x
Abstract: Autophagy, a process for self-degradation of intracellular components and dysfunctional organelles, is closely related with neurodegenerative diseases. It has been shown that cadmium (Cd) induces neurotoxicity partly by impairing autophagy. However, the underlying mechanism is… read more here.
Keywords: neuronal cells; expansion; jnk; ca2 ... See more keywords
Naringenin Upregulates AMPK-Mediated Autophagy to Rescue Neuronal Cells From β-Amyloid (1–42) Evoked Neurotoxicity
Sign Up to like & getrecommendations! Published in 2020 at "Molecular Neurobiology"
DOI: 10.1007/s12035-020-01969-4
Abstract: Deposition of an amyloid-β peptide is one of the first events in the pathophysiology of Alzheimer’s disease (AD) and is clinically characterized by Aβ plaques, tau tangles, and behavioral impairments that lead to neuronal death.… read more here.
Keywords: neuronal cells; mediated autophagy; naringenin; evoked neurotoxicity ... See more keywords
A simple and efficient toolset for analysing mitochondrial trafficking in neuronal cells.
Sign Up to like & getrecommendations! Published in 2018 at "Acta histochemica"
DOI: 10.1016/j.acthis.2018.09.001
Abstract: Mitochondria are crucial for cells, supplying up to 90% of the energy requirements for neurons. Their correct localisation is crucial and ensured by a transport system. Mitochondrial trafficking in neurons is particularly critical, because mitochondria… read more here.
Keywords: mitochondrial trafficking; neuronal cells; mitrakd; analysing mitochondrial ... See more keywords
AntagomiR-613 protects neuronal cells from oxygen glucose deprivation/re-oxygenation via increasing SphK2 expression.
Sign Up to like & getrecommendations! Published in 2017 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2017.09.049
Abstract: Oxygen glucose deprivation (OGD)/re-oxygenation (OGDR) causes damages to neuronal cells. Sphingosine kinase 2 (SphK2) expression could exert neuroprotective functions. Here, we aim to induce SphK2 expression via inhibiting the anti-SphK2 microRNA: microRNA-613 ("miR-613"). In both… read more here.
Keywords: neuronal cells; antamir 613; mir 613; expression ... See more keywords
Modeling Single-Molecule Conformations of the HoxD Region in Mouse Embryonic Stem and Cortical Neuronal Cells.
Sign Up to like & getrecommendations! Published in 2019 at "Cell reports"
DOI: 10.1016/j.celrep.2019.07.013
Abstract: Complex architectural rearrangements are associated to the control of the HoxD genes in different cell types; yet, how they are implemented in single cells remains unknown. By use of polymer models, we dissect the locus… read more here.
Keywords: neuronal cells; cortical neuronal; mouse embryonic; stem cortical ... See more keywords