Nanoscale‐tipped wire array injections transfer DNA directly into brain cells ex vivo and in vivo
Sign Up to like & getrecommendations! Published in 2022 at "FEBS Open Bio"
DOI: 10.1002/2211-5463.13377
Abstract: Genetic modification to restore cell functions in the brain can be performed through the delivery of biomolecules in a minimally invasive manner into live neuronal cells within brain tissues. However, conventional nanoscale needles are too… read more here.
Keywords: brain; vivo vivo; neuronal cells; wire ... See more keywords
Higenamine protects neuronal cells from oxygen‐glucose deprivation/reoxygenation‐induced injury
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular Biochemistry"
DOI: 10.1002/jcb.27656
Abstract: Higenamine, a plant‐based alkaloid, exhibits various properties, such as antiapoptotic and antioxidative effects. Previous studies proved that higenamine possesses potential therapeutic effects for ischemia/reperfusion (I/R) injuries. However, the role of higenamine in cerebral I/R injury… read more here.
Keywords: neuronal cells; higenamine; glucose deprivation; higenamine protects ... See more keywords
Expression and Functional Study of Single Mutations of Carbonic Anhydrase 8 in Neuronal Cells
Sign Up to like & getrecommendations! Published in 2020 at "Cellular and Molecular Neurobiology"
DOI: 10.1007/s10571-020-00907-1
Abstract: Carbonic anhydrase 8 (CA8), an isozyme of α-carbonic anhydrases, lacks the ability to catalyze the reversible hydration of CO 2 to bicarbonate and proton. Previous studies have shown that single point mutations of CA8, CA8-S100P,… read more here.
Keywords: neuronal cells; ca8 g162r; s100p ca8; ca8 s100p ... See more keywords
Cadmium Impairs Autophagy Leading to Apoptosis by Ca2+-Dependent Activation of JNK Signaling Pathway in Neuronal Cells.
Sign Up to like & getrecommendations! Published in 2021 at "Neurochemical research"
DOI: 10.1007/s11064-021-03341-x
Abstract: Autophagy, a process for self-degradation of intracellular components and dysfunctional organelles, is closely related with neurodegenerative diseases. It has been shown that cadmium (Cd) induces neurotoxicity partly by impairing autophagy. However, the underlying mechanism is… read more here.
Keywords: neuronal cells; expansion; jnk; ca2 ... See more keywords
Naringenin Upregulates AMPK-Mediated Autophagy to Rescue Neuronal Cells From β-Amyloid (1–42) Evoked Neurotoxicity
Sign Up to like & getrecommendations! Published in 2020 at "Molecular Neurobiology"
DOI: 10.1007/s12035-020-01969-4
Abstract: Deposition of an amyloid-β peptide is one of the first events in the pathophysiology of Alzheimer’s disease (AD) and is clinically characterized by Aβ plaques, tau tangles, and behavioral impairments that lead to neuronal death.… read more here.
Keywords: neuronal cells; mediated autophagy; naringenin; evoked neurotoxicity ... See more keywords
A simple and efficient toolset for analysing mitochondrial trafficking in neuronal cells.
Sign Up to like & getrecommendations! Published in 2018 at "Acta histochemica"
DOI: 10.1016/j.acthis.2018.09.001
Abstract: Mitochondria are crucial for cells, supplying up to 90% of the energy requirements for neurons. Their correct localisation is crucial and ensured by a transport system. Mitochondrial trafficking in neurons is particularly critical, because mitochondria… read more here.
Keywords: mitochondrial trafficking; neuronal cells; mitrakd; analysing mitochondrial ... See more keywords
AntagomiR-613 protects neuronal cells from oxygen glucose deprivation/re-oxygenation via increasing SphK2 expression.
Sign Up to like & getrecommendations! Published in 2017 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2017.09.049
Abstract: Oxygen glucose deprivation (OGD)/re-oxygenation (OGDR) causes damages to neuronal cells. Sphingosine kinase 2 (SphK2) expression could exert neuroprotective functions. Here, we aim to induce SphK2 expression via inhibiting the anti-SphK2 microRNA: microRNA-613 ("miR-613"). In both… read more here.
Keywords: neuronal cells; antamir 613; mir 613; expression ... See more keywords
Modeling Single-Molecule Conformations of the HoxD Region in Mouse Embryonic Stem and Cortical Neuronal Cells.
Sign Up to like & getrecommendations! Published in 2019 at "Cell reports"
DOI: 10.1016/j.celrep.2019.07.013
Abstract: Complex architectural rearrangements are associated to the control of the HoxD genes in different cell types; yet, how they are implemented in single cells remains unknown. By use of polymer models, we dissect the locus… read more here.
Keywords: neuronal cells; cortical neuronal; mouse embryonic; stem cortical ... See more keywords
Ferruginol prevents degeneration of dopaminergic neurons by enhancing clearance of α-synuclein in neuronal cells.
Sign Up to like & getrecommendations! Published in 2021 at "Fitoterapia"
DOI: 10.1016/j.fitote.2021.105066
Abstract: Lewy bodies are characteristic spherical inclusions in Parkinson's disease (PD) that are formed by α-synuclein fibrils. Ferruginol (Fer) is an amonomeric compound isolated from a traditional Chinese herb. Here, we show that Fer exerted potent… read more here.
Keywords: neuronal cells; synuclein; fer; clearance synuclein ... See more keywords
Effect of uremic toxins on hippocampal cell damage: analysis in vitro and in rat model of chronic kidney disease
Sign Up to like & getrecommendations! Published in 2021 at "Heliyon"
DOI: 10.1016/j.heliyon.2021.e06221
Abstract: One third of the patients with chronic kidney disease (CKD) develop cognitive impairment, which is also an independent risk factor for mortality. However, the concise mechanism of cerebro-renal interaction has not been clarified. The present… read more here.
Keywords: uremic toxins; neuronal cells; kidney disease; chronic kidney ... See more keywords
Proteins involved in actin filament organization are key host factors for Japanese encephalitis virus life-cycle in human neuronal cells.
Sign Up to like & getrecommendations! Published in 2020 at "Microbial pathogenesis"
DOI: 10.1016/j.micpath.2020.104565
Abstract: Multiple membrane trafficking networks operate in the eukaryotic cell and are hijacked by viruses to establish infection. Recent studied have highlighted that viruses can exploit distinct pathways depending on the cell type. Japanese encephalitis virus… read more here.
Keywords: encephalitis virus; neuronal cells; host factors; proteins involved ... See more keywords