Functional mosaic organization of neuroligins in neuronal circuits
Sign Up to like & getrecommendations! Published in 2020 at "Cellular and Molecular Life Sciences"
DOI: 10.1007/s00018-020-03478-y
Abstract: Complex brain circuitry with feedforward and feedback systems regulates neuronal activity, enabling neural networks to process and drive the entire spectrum of cognitive, behavioral, sensory, and motor functions. Simultaneous orchestration of distinct cells and interconnected… read more here.
Keywords: adhesion molecules; mosaic organization; organization neuroligins; neuroligins neuronal ... See more keywords
Brain organoids: Human 3D models to investigate neuronal circuits assembly, function and dysfunction
Sign Up to like & getrecommendations! Published in 2020 at "Brain Research"
DOI: 10.1016/j.brainres.2020.147028
Abstract: The human brain is characterized by an extraordinary complexity of neuronal and nonneuronal cell types, wired together into patterned neuronal circuits, which represent the anatomical substrates for the execution of high-order cognitive functions. Brain circuits'… read more here.
Keywords: organoid protocols; human brain; brain organoids; brain organoid ... See more keywords
Nanoscale Patterning of In Vitro Neuronal Circuits.
Sign Up to like & getrecommendations! Published in 2022 at "ACS nano"
DOI: 10.1021/acsnano.1c10750
Abstract: Methods for patterning neurons in vitro have gradually improved and are used to investigate questions that are difficult to address in or ex vivo. Though these techniques guide axons between groups of neurons, multiscale control… read more here.
Keywords: nanoscale patterning; vitro neuronal; patterning vitro; neuronal circuits ... See more keywords
Microglia‐dependent remodeling of neuronal circuits
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Neurochemistry"
DOI: 10.1111/jnc.15689
Abstract: Microglia are tissue‐resident macrophages responsible for the surveillance, neuronal support, and immune defense of the brain parenchyma. Recently, the role played by microglia in the formation and function of neuronal circuits has garnered substantial attention.… read more here.
Keywords: brain; neuronal circuits; microglia dependent; dependent remodeling ... See more keywords
Functional neuronal circuits promote disease progression in cancer
Sign Up to like & getrecommendations! Published in 2023 at "Science Advances"
DOI: 10.1126/sciadv.ade4443
Abstract: The molecular and functional contributions of intratumoral nerves to disease remain largely unknown. We localized synaptic markers within tumors suggesting that these nerves form functional connections. Consistent with this, electrophysiological analysis shows that malignancies harbor… read more here.
Keywords: progression; neuronal circuits; intratumoral nerves; functional neuronal ... See more keywords
Manipulating neuronal circuits, in concert
Sign Up to like & getrecommendations! Published in 2021 at "Science"
DOI: 10.1126/science.abj5260
Abstract: Two-photon holographic optogenetics enables precise modulation of brain activity Perception and behavior emerge from the coordinated and orchestrated activity of neurons in brain circuits. Individual, functionally coherent neurons form ensembles, which become the building blocks… read more here.
Keywords: medicine; circuits concert; manipulating neuronal; brain ... See more keywords
Developmental loss of neurofibromin across distributed neuronal circuits drives excessive grooming in Drosophila
Sign Up to like & getrecommendations! Published in 2020 at "PLoS Genetics"
DOI: 10.1371/journal.pgen.1008920
Abstract: Neurofibromatosis type 1 is a monogenetic disorder that predisposes individuals to tumor formation and cognitive and behavioral symptoms. The neuronal circuitry and developmental events underlying these neurological symptoms are unknown. To better understand how mutations… read more here.
Keywords: developmental loss; neurofibromin across; grooming drosophila; loss neurofibromin ... See more keywords
Targeting the Brain to Cure Type 2 Diabetes
Sign Up to like & getrecommendations! Published in 2019 at "Diabetes"
DOI: 10.2337/dbi18-0051
Abstract: Present pharmacological treatments of type 2 diabetes aim mainly at increasing insulin secretion by pancreatic β-cells, at improving insulin action on liver, fat, or muscle, and, more recently, at favoring renal glucose elimination. Although efficacious,… read more here.
Keywords: brain cure; targeting brain; type diabetes; neuronal circuits ... See more keywords
The Role of Ghrelin in Regulating Synaptic Function and Plasticity of Feeding-Associated Circuits
Sign Up to like & getrecommendations! Published in 2019 at "Frontiers in Cellular Neuroscience"
DOI: 10.3389/fncel.2019.00205
Abstract: Synaptic plasticity of the neuronal circuits associated with feeding behavior is regulated by peripheral signals as a response to changes in the energy status of the body. These signals include glucose, free fatty acids, leptin… read more here.
Keywords: feeding; ghrelin regulating; synaptic plasticity; plasticity ... See more keywords
Impact of Physical Obstacles on the Structural and Effective Connectivity of in silico Neuronal Circuits
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Computational Neuroscience"
DOI: 10.3389/fncom.2020.00077
Abstract: Scaffolds and patterned substrates are among the most successful strategies to dictate the connectivity between neurons in culture. Here, we used numerical simulations to investigate the capacity of physical obstacles placed on a flat substrate… read more here.
Keywords: effective connectivity; connectivity; obstacles structural; physical obstacles ... See more keywords