Striatal neurons directly converted from Huntington’s disease patient fibroblasts recapitulate age-associated disease phenotypes
Sign Up to like & getrecommendations! Published in 2018 at "Nature neuroscience"
DOI: 10.1038/s41593-018-0075-7
Abstract: In Huntington’s disease (HD), expansion of CAG codons in the huntingtin gene (HTT) leads to the aberrant formation of protein aggregates and the differential degeneration of striatal medium spiny neurons (MSNs). Modeling HD using patient-specific… read more here.
Keywords: patient fibroblasts; age; huntington disease; disease ... See more keywords
Chemical Replacement of Noggin with Dorsomorphin Homolog 1 for Cost-Effective Direct Neuronal Conversion
Sign Up to like & getrecommendations! Published in 2022 at "Cellular Reprogramming"
DOI: 10.1089/cell.2021.0200
Abstract: The direct conversion of adult human skin fibroblasts (FBs) into induced neurons (iNs) represents a useful technology to generate donor-specific adult-like human neurons. Disease modeling studies rely on the consistently efficient conversion of relatively large… read more here.
Keywords: noggin; conversion; dorsomorphin homolog; dmh1 ... See more keywords
Ascl1 phospho-site mutations enhance neuronal conversion of adult cortical astrocytes in vivo
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Neuroscience"
DOI: 10.3389/fnins.2022.917071
Abstract: Direct neuronal reprogramming, the process whereby a terminally differentiated cell is converted into an induced neuron without traversing a pluripotent state, has tremendous therapeutic potential for a host of neurodegenerative diseases. While there is strong… read more here.
Keywords: conversion adult; adult; ascl1sa6; conversion ... See more keywords