microRNA‐124 regulates Notch and NeuroD1 to mediate transition states of neuronal development
Sign Up to like & getrecommendations! Published in 2022 at "Developmental Neurobiology"
DOI: 10.1002/dneu.22902
Abstract: MicroRNAs regulate gene expression by destabilizing target mRNA and/or inhibiting translation in animal cells. The ability to mechanistically dissect miR‐124′s function during specification, differentiation, and maturation of neurons during development within a single system has… read more here.
Keywords: regulates notch; mir 124; development; 124 regulates ... See more keywords
Brain‐derived neurotrophic factor‐induced regulation of RNA metabolism in neuronal development and synaptic plasticity
Sign Up to like & getrecommendations! Published in 2022 at "Wiley Interdisciplinary Reviews: RNA"
DOI: 10.1002/wrna.1713
Abstract: The neurotrophin brain‐derived neurotrophic factor (BDNF) plays multiple roles in the nervous system, including in neuronal development, in long‐term synaptic potentiation in different brain regions, and in neuronal survival. Alterations in these regulatory mechanisms account… read more here.
Keywords: derived neurotrophic; development; brain derived; neuronal development ... See more keywords
Maternal exposure to volatile anesthetics induces IL-6 in fetal brains and affects neuronal development.
Sign Up to like & getrecommendations! Published in 2019 at "European journal of pharmacology"
DOI: 10.1016/j.ejphar.2019.172682
Abstract: Most clinically used general anesthetics have demonstrated neurotoxicity in animal studies, but the related mechanisms remain unknown. Previous studies suggest that anesthetics affect neuronal development through neuroinflammation, and significant effects of neuroinflammation on neurogenesis and… read more here.
Keywords: neuronal development; volatile anesthetics; fetal brains; maternal exposure ... See more keywords
GWAS links variants in neuronal development and actin remodeling related loci with pseudoexfoliation syndrome without glaucoma
Sign Up to like & getrecommendations! Published in 2018 at "Experimental Eye Research"
DOI: 10.1016/j.exer.2017.12.006
Abstract: ABSTRACT Pseudoexfoliation syndrome (PEXS) is an age‐related elastosis, strongly associated with the development of secondary glaucoma. It is clearly suggested that PEXS has a genetic component, but this has not been extensively studied. Here, a… read more here.
Keywords: snps; pexs; without glaucoma; neuronal development ... See more keywords
Translational derepression of Elavl4 isoforms at their alternative 5′ UTRs determines neuronal development
Sign Up to like & getrecommendations! Published in 2020 at "Nature Communications"
DOI: 10.1038/s41467-020-15412-8
Abstract: Neurodevelopment requires precise regulation of gene expression, including post-transcriptional regulatory events such as alternative splicing and mRNA translation. However, translational regulation of specific isoforms during neurodevelopment and the mechanisms behind it remain unknown. Using RNA-seq… read more here.
Keywords: post transcriptional; alternative utrs; neuronal development; translation ... See more keywords
3β, 6β-dichloro-5-hydroxy-5α-cholestane facilitates neuronal development through modulating TrkA signaling regulated proteins in primary hippocampal neuron
Sign Up to like & getrecommendations! Published in 2019 at "Scientific Reports"
DOI: 10.1038/s41598-019-55364-8
Abstract: Potentiating neuritogenesis through pharmacological intervention might hold therapeutic promise in neurodegenerative disorders and acute brain injury. Here, we investigated the novel neuritogenic potentials of a steroidal chlorohydrin, 3β, 6β-dichloro-5-hydroxy-5α-cholestane (hereafter, SCH) and the change in… read more here.
Keywords: dichloro hydroxy; trka signaling; neuronal development; development ... See more keywords
Metabolic Regulation of Hippocampal Neuronal Development and Its Inhibition After Irradiation.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of neuropathology and experimental neurology"
DOI: 10.1093/jnen/nlab014
Abstract: 5'-Adenosine monophosphate-activated protein kinase (AMPK), a key regulator of cellular energy homeostasis, plays a role in cell fate determination. Whether AMPK regulates hippocampal neuronal development remains unclear. Hippocampal neurogenesis is abrogated after DNA damage. Here,… read more here.
Keywords: hippocampal neuronal; irradiation; inhibition; ampk ... See more keywords
MYT1L is required for suppressing earlier neuronal development programs in the adult mouse brain
Sign Up to like & getrecommendations! Published in 2022 at "Genome Research"
DOI: 10.1101/2022.10.17.512591
Abstract: In vitro studies indicate the neurodevelopmental disorder gene Myelin Transcription Factor 1 Like (MYT1L) suppresses non-neuronal lineage genes during fibroblast-to-neuron direct differentiation. However, MYT1L’s molecular and cellular functions during differentiation in the mammalian brain have… read more here.
Keywords: myt1l; development; brain; earlier neuronal ... See more keywords
Deneddylating enzyme SENP8 regulates neuronal development
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Neurochemistry"
DOI: 10.1111/jnc.15797
Abstract: Neddylation is a cellular process in which the neural precursor cell expressed, developmentally down‐regulated 8 (NEDD8) is conjugated to the lysine residue of target proteins via serial enzymatic cascades. Recently, it has been demonstrated that… read more here.
Keywords: development; neddylation; neuronal development; neurite outgrowth ... See more keywords
Mitochondria metabolism sets the species-specific tempo of neuronal development
Sign Up to like & getrecommendations! Published in 2023 at "Science"
DOI: 10.1126/science.abn4705
Abstract: Neuronal development in the human cerebral cortex is considerably prolonged compared with that of other mammals. We explored whether mitochondria influence the species-specific timing of cortical neuron maturation. By comparing human and mouse cortical neuronal… read more here.
Keywords: metabolism; maturation; mouse neurons; development ... See more keywords
Neuronal Development of Hearing and Language: Cochlear Implants and Critical Periods.
Sign Up to like & getrecommendations! Published in 2019 at "Annual review of neuroscience"
DOI: 10.1146/annurev-neuro-080317-061513
Abstract: The modern cochlear implant (CI) is the most successful neural prosthesis developed to date. CIs provide hearing to the profoundly hearing impaired and allow the acquisition of spoken language in children born deaf. Results from… read more here.
Keywords: development hearing; hearing language; neuronal development; language cochlear ... See more keywords