Cdyl Deficiency Brakes Neuronal Excitability and Nociception through Promoting Kcnb1 Transcription in Peripheral Sensory Neurons
Sign Up to like & getrecommendations! Published in 2022 at "Advanced Science"
DOI: 10.1002/advs.202104317
Abstract: Epigenetic modifications are involved in the onset, development, and maintenance of pain; however, the precise epigenetic mechanism underlying pain regulation remains elusive. Here it is reported that the epigenetic factor chromodomain Y‐like (CDYL) is crucial… read more here.
Keywords: neuronal excitability; excitability nociception; nociception; pain ... See more keywords
ECS Dynamism and Its Influence on Neuronal Excitability and Seizures
Sign Up to like & getrecommendations! Published in 2019 at "Neurochemical Research"
DOI: 10.1007/s11064-019-02773-w
Abstract: Seizure activity is governed by changes in normal neuronal physiology that lead to a state of neuronal hyperexcitability and synchrony. There is a growing body of research and evidence suggesting that alterations in the volume… read more here.
Keywords: neuronal excitability; physiology; ecs volume; volume ... See more keywords
Eugenol induces body immobilization yet evoking an increased neuronal excitability in fish during short-term baths.
Sign Up to like & getrecommendations! Published in 2020 at "Aquatic toxicology"
DOI: 10.1016/j.aquatox.2020.105734
Abstract: Several studies have suggested eugenol as a suitable anaesthetic for fish. However, it has also been regarded as a toxic and aversive substance to several aquatic organisms, including fish. This study sought to assess the… read more here.
Keywords: eugenol; neuronal excitability; ptz; body immobilization ... See more keywords
Alkaloids from Corydalis decumbens modulate neuronal excitability.
Sign Up to like & getrecommendations! Published in 2020 at "Bioorganic chemistry"
DOI: 10.1016/j.bioorg.2020.103795
Abstract: Eight new alkaloids, including five isoquinoline alkaloids, a benzoazepine alkaloid, two isoindole alkaloids, and three synthetic alkaloids firstly obtained from the natural sources, together with three known ones were isolated from the bulbs of Corydalis… read more here.
Keywords: neuronal excitability; corydalis decumbens; chemistry; decumbens modulate ... See more keywords
Niemann-Pick Type C Disease Reveals a Link between Lysosomal Cholesterol and PtdIns(4,5)P2 That Regulates Neuronal Excitability
Sign Up to like & getrecommendations! Published in 2019 at "Cell reports"
DOI: 10.1016/j.celrep.2019.04.099
Abstract: SUMMARY There is increasing evidence that the lysosome is involved in the pathogenesis of a variety of neurodegenerative disorders. Thus, mechanisms that link lysosome dysfunction to the disruption of neuronal homeostasis offer opportunities to understand… read more here.
Keywords: neuronal excitability; niemann pick; lysosomal cholesterol; disease ... See more keywords
KCC2 Regulates Neuronal Excitability and Hippocampal Activity via Interaction with Task-3 Channels.
Sign Up to like & getrecommendations! Published in 2019 at "Cell reports"
DOI: 10.1016/j.celrep.2019.06.001
Abstract: KCC2 regulates neuronal transmembrane chloride gradients and thereby controls GABA signaling in the brain. KCC2 downregulation is observed in numerous neurological and psychiatric disorders. Paradoxical, excitatory GABA signaling is usually assumed to contribute to abnormal… read more here.
Keywords: regulates neuronal; neuronal excitability; kcc2 regulates; downregulation ... See more keywords
Neuronal excitability and spontaneous synaptic transmission in the entorhinal cortex of BDNF heterozygous mice
Sign Up to like & getrecommendations! Published in 2019 at "Neuroscience Letters"
DOI: 10.1016/j.neulet.2018.10.019
Abstract: Brain Derived Neurotropic Factor (BDNF) is a neutrophic factor that is required for the normal neuronal development and function. BDNF is involved in regulation of synapses as well as neuronal excitability. Entorhinal Cortex (EC) is… read more here.
Keywords: entorhinal cortex; neuronal excitability; spontaneous synaptic; bdnf ... See more keywords
Immediate and cumulative effects of high-frequency repetitive transcranial magnetic stimulation on cognition and neuronal excitability in mice
Sign Up to like & getrecommendations! Published in 2021 at "Neuroscience research"
DOI: 10.1016/j.neures.2021.05.015
Abstract: This study primarily explored the potential effects of high-frequency (20 Hz) repetitive transcranial magnetic stimulation (rTMS) with different intervention protocols on cognition and neuronal excitability in mice. Mice were randomly divided into 4 groups: a… read more here.
Keywords: stimulation; neuronal excitability; rtms; high frequency ... See more keywords
Differential regulation of neuronal excitability by nicotine and substance P in subdivisions of the medial habenula
Sign Up to like & getrecommendations! Published in 2018 at "Animal Cells and Systems"
DOI: 10.1080/19768354.2018.1456485
Abstract: ABSTRACT The medial habenula (MHb) plays an important role in nicotine-related behaviors, such as aversion and withdrawal. The MHb is composed of distinct subregions with unique neurotransmitter expression and neuronal connectivity. Here, we showed that… read more here.
Keywords: neuronal excitability; mhb; excitability; nicotine substance ... See more keywords
RTL1/PEG11 imprinted in human and mouse brain mediates anxiety-like and social behaviors and regulates neuronal excitability in the locus coeruleus
Sign Up to like & getrecommendations! Published in 2022 at "Human Molecular Genetics"
DOI: 10.1093/hmg/ddac110
Abstract: Abstract RTL1/PEG11, which has been associated with anxiety disorders, is a retrotransposon-derived imprinted gene in the placenta. However, imprinting patterns and functions of RTL1 in the brain have not been well-investigated. We found Rtl1 was… read more here.
Keywords: locus coeruleus; neuronal excitability; brain mediates; brain ... See more keywords
PRMT7 modulates neuronal excitability by interacting with NaV1.9.
Sign Up to like & getrecommendations! Published in 2021 at "Pain"
DOI: 10.1097/j.pain.0000000000002421
Abstract: ABSTRACT Human NaV1.9 (hNaV1.9), encoded by SCN11A, is preferentially expressed in nociceptors, and its mutations have been linked to pain disorders. NaV1.9 could be a promising drug target for pain relief. However, the modulation of… read more here.
Keywords: neuronal excitability; scn11a mice; prmt7 modulates; prmt7 ... See more keywords