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Published in 2020 at "Cell reports"
DOI: 10.1016/j.celrep.2020.108169
Abstract: SUMMARY Neuronal hyperactivity is an early primary dysfunction in Alzheimer’s disease (AD) in humans and animal models, but effective neuronal hyperactivity-directed anti-AD therapeutic agents are lacking. Here we define a previously unknown mode of ryanodine…
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Keywords:
hyperactivity;
open time;
neuronal hyperactivity;
ryr2 open ... See more keywords
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1
Published in 2022 at "Aging Cell"
DOI: 10.1111/acel.13592
Abstract: Delirium is the most common postoperative complication in older patients after prolonged anesthesia and surgery and is associated with accelerated cognitive decline and dementia. The neuronal pathogenesis of postoperative delirium is largely unknown. The unfolded…
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Keywords:
unfolded protein;
loss;
aged mice;
neuronal hyperactivity ... See more keywords
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Published in 2022 at "Science Advances"
DOI: 10.1126/sciadv.abn0356
Abstract: Interneuronal transfer and brain spreading of pathogenic proteins are features of neurodegenerative diseases. Pathophysiological conditions and mechanisms affecting this spreading remain poorly understood. This study investigated the relationship between neuronal activity and interneuronal transfer of…
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Keywords:
brain spreading;
hyperactivity induced;
neuronal hyperactivity;
hyperactivity ... See more keywords
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Published in 2020 at "Cancer discovery"
DOI: 10.1158/2159-8290.cd-rw2020-019
Abstract: Two glioma driver mutations in PIK3CA promote neuronal hyperactivity via distinct mechanisms.
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Keywords:
glioma;
induce neuronal;
mutations induce;
neuronal hyperactivity ... See more keywords