Articles with "neuronal hyperactivity" as a keyword



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Limiting RyR2 Open Time Prevents Alzheimer’s Disease-Related Neuronal Hyperactivity and Memory Loss but Not β-Amyloid Accumulation

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Published in 2020 at "Cell reports"

DOI: 10.1016/j.celrep.2020.108169

Abstract: SUMMARY Neuronal hyperactivity is an early primary dysfunction in Alzheimer’s disease (AD) in humans and animal models, but effective neuronal hyperactivity-directed anti-AD therapeutic agents are lacking. Here we define a previously unknown mode of ryanodine… read more here.

Keywords: hyperactivity; open time; neuronal hyperactivity; ryr2 open ... See more keywords

Inhibition of unfolded protein response prevents post‐anesthesia neuronal hyperactivity and synapse loss in aged mice

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Published in 2022 at "Aging Cell"

DOI: 10.1111/acel.13592

Abstract: Delirium is the most common postoperative complication in older patients after prolonged anesthesia and surgery and is associated with accelerated cognitive decline and dementia. The neuronal pathogenesis of postoperative delirium is largely unknown. The unfolded… read more here.

Keywords: unfolded protein; loss; aged mice; neuronal hyperactivity ... See more keywords
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Neuronal hyperactivity–induced oxidant stress promotes in vivo α-synuclein brain spreading

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Published in 2022 at "Science Advances"

DOI: 10.1126/sciadv.abn0356

Abstract: Interneuronal transfer and brain spreading of pathogenic proteins are features of neurodegenerative diseases. Pathophysiological conditions and mechanisms affecting this spreading remain poorly understood. This study investigated the relationship between neuronal activity and interneuronal transfer of… read more here.

Keywords: brain spreading; hyperactivity induced; neuronal hyperactivity; hyperactivity ... See more keywords
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PIK3CA Mutations Induce Neuronal Hyperactivity during Glioma Formation.

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Published in 2020 at "Cancer discovery"

DOI: 10.1158/2159-8290.cd-rw2020-019

Abstract: Two glioma driver mutations in PIK3CA promote neuronal hyperactivity via distinct mechanisms. read more here.

Keywords: glioma; induce neuronal; mutations induce; neuronal hyperactivity ... See more keywords