Limiting RyR2 Open Time Prevents Alzheimer’s Disease-Related Neuronal Hyperactivity and Memory Loss but Not β-Amyloid Accumulation
Sign Up to like & getrecommendations! Published in 2020 at "Cell reports"
DOI: 10.1016/j.celrep.2020.108169
Abstract: SUMMARY Neuronal hyperactivity is an early primary dysfunction in Alzheimer’s disease (AD) in humans and animal models, but effective neuronal hyperactivity-directed anti-AD therapeutic agents are lacking. Here we define a previously unknown mode of ryanodine… read more here.
Keywords: hyperactivity; open time; neuronal hyperactivity; ryr2 open ... See more keywords
Inhibition of unfolded protein response prevents post‐anesthesia neuronal hyperactivity and synapse loss in aged mice
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DOI: 10.1111/acel.13592
Abstract: Delirium is the most common postoperative complication in older patients after prolonged anesthesia and surgery and is associated with accelerated cognitive decline and dementia. The neuronal pathogenesis of postoperative delirium is largely unknown. The unfolded… read more here.
Keywords: unfolded protein; loss; aged mice; neuronal hyperactivity ... See more keywords
Neuronal hyperactivity–induced oxidant stress promotes in vivo α-synuclein brain spreading
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DOI: 10.1126/sciadv.abn0356
Abstract: Interneuronal transfer and brain spreading of pathogenic proteins are features of neurodegenerative diseases. Pathophysiological conditions and mechanisms affecting this spreading remain poorly understood. This study investigated the relationship between neuronal activity and interneuronal transfer of… read more here.
Keywords: brain spreading; hyperactivity induced; neuronal hyperactivity; hyperactivity ... See more keywords
PIK3CA Mutations Induce Neuronal Hyperactivity during Glioma Formation.
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DOI: 10.1158/2159-8290.cd-rw2020-019
Abstract: Two glioma driver mutations in PIK3CA promote neuronal hyperactivity via distinct mechanisms. read more here.
Keywords: glioma; induce neuronal; mutations induce; neuronal hyperactivity ... See more keywords