M-Current Suppression, Seizures and Lipid Metabolism: A Potential Link Between Neuronal Kv7 Channel Regulation and Dietary Therapies for Epilepsy
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Physiology"
DOI: 10.3389/fphys.2020.00513
Abstract: Neuronal Kv7 channel generates a low voltage-activated potassium current known as the M-current. The M-current can be suppressed by various neurotransmitters that activate Gq-coupled receptors. Because the M-current stabilizes membrane potential at the resting membrane… read more here.
Keywords: neuronal kv7; channel; kv7 channel; current suppression ... See more keywords
Cannabidiol activates neuronal Kv7 channels
Sign Up to like & getrecommendations! Published in 2022 at "eLife"
DOI: 10.7554/elife.73246
Abstract: Cannabidiol (CBD), a chemical found in the Cannabis sativa plant, is a clinically effective antiepileptic drug whose mechanism of action is unknown. Using a fluorescence-based thallium flux assay, we performed a large-scale screen and found… read more here.
Keywords: neuronal kv7; cannabidiol activates; kv7; activates neuronal ... See more keywords