TREM2 triggers microglial density and age‐related neuronal loss
Sign Up to like & getrecommendations! Published in 2019 at "Glia"
DOI: 10.1002/glia.23563
Abstract: The microglial triggering receptor expressed on myeloid cells 2 (TREM2) signals via the activatory membrane adaptor molecule TYROBP. Genetic variants or mutations of TREM2 or TYROBP have been linked to inflammatory neurodegenerative diseases associated with… read more here.
Keywords: trem2 knock; trem2; age related; neuronal loss ... See more keywords
Alzheimer's disease‐associated R47H TREM2 increases, but wild‐type TREM2 decreases, microglial phagocytosis of synaptosomes and neuronal loss
Sign Up to like & getrecommendations! Published in 2022 at "Glia"
DOI: 10.1002/glia.24318
Abstract: Triggering receptor on myeloid cells 2 (TREM2) is an innate immune receptor, upregulated on the surface of microglia associated with amyloid plaques in Alzheimer's disease (AD). Individuals heterozygous for the R47H variant of TREM2 have… read more here.
Keywords: r47h trem2; trem2; phagocytosis; neuronal loss ... See more keywords
Dextromethorphan reduces prenatal lipopolysaccharide exposure‐induced dopaminergic neuronal loss and cytokine changes in offspring
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Developmental Neuroscience"
DOI: 10.1002/jdn.10180
Abstract: Maternal infection during pregnancy may affect fetal brain development and increase the risk of developing neurological and mental disorders later in life in offspring. In this study, we used low‐dose lipopolysaccharide (LPS) injection to mimic… read more here.
Keywords: dopaminergic neuronal; dextromethorphan; neuronal loss; maternal infection ... See more keywords
Orally Administered Cinnamon Extract Attenuates Cognitive and Neuronal Deficits Following Traumatic Brain Injury
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Molecular Neuroscience"
DOI: 10.1007/s12031-020-01688-4
Abstract: The present paper shows how cinnamon extract (CE) consumption mitigates neuronal loss and memory impairment following traumatic brain injury (TBI), one of the world’s most common neurodegenerative diseases. TBI patients suffer short- and long-term behavioral,… read more here.
Keywords: traumatic brain; neuronal loss; cinnamon extract; following traumatic ... See more keywords
Clinical and pathological definition of temporal medium epilepsy subtypes with hypocampic sclerosis
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DOI: 10.1016/j.neucie.2017.12.002
Abstract: Abstract Background and objective Mesial temporal lobe epilepsy with hippocampal sclerosis is the most common cause of refractory epilepsy, and the most common indication for surgery. Although effective, surgery fails in up to 40% of… read more here.
Keywords: epilepsy; sclerosis; hippocampal sclerosis; neuronal loss ... See more keywords
HDAC1 deregulation promotes neuronal loss and deficit of motor function in stroke pathogenesis
Sign Up to like & getrecommendations! Published in 2021 at "Scientific Reports"
DOI: 10.1038/s41598-021-95837-3
Abstract: Stroke is a common cause of death worldwide and leads to disability and cognitive dysfunction. Ischemic stroke and hemorrhagic stroke are major categories of stroke, accounting for 68% and 32% of strokes, respectively. Each year,… read more here.
Keywords: neuronal loss; pathogenesis; hdac1; stroke pathogenesis ... See more keywords
Administration of Vitamin D3 and E supplements reduces neuronal loss and oxidative stress in a model of rats with Alzheimer’s disease
Sign Up to like & getrecommendations! Published in 2020 at "Neurological Research"
DOI: 10.1080/01616412.2020.1787624
Abstract: ABSTRACT Introduction Alzheimer’s disease (AD) is the most common neurodegenerative disease across the world. The major cause of AD is extensive oxidative stress and inflammation in central nervous system (CNS). Vitamin D3 and E are… read more here.
Keywords: neuronal loss; vitamin; group; oxidative stress ... See more keywords
Lesion extension and neuronal loss following spinal cord injury using X-ray phase-contrast tomography in mice.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of neurotrauma"
DOI: 10.1089/neu.2021.0451
Abstract: Following a spinal cord injury (SCI) the degree of functional (motor, autonomous or sensory) correlates with the severity of nervous tissue disruption. An imaging technique able to capture non-invasively and simultaneously the complex mechanisms of… read more here.
Keywords: following spinal; cord injury; contrast; loss ... See more keywords
Neocortical Neuronal Loss in Patients with Multiple System Atrophy: A Stereological Study
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DOI: 10.1093/cercor/bhv228
Abstract: Abstract To determine the extent of neocortical involvement in multiple system atrophy (MSA), we used design‐based stereological methods to estimate the total numbers of neurons, oligodendrocytes, astrocytes, and microglia in the frontal, parietal, temporal, and… read more here.
Keywords: cortex; neuronal loss; system atrophy; msa ... See more keywords
Progressive Neuronal Loss in Epilepsy – A Long-Standing Conundrum Finally Resolved?
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DOI: 10.1177/15357597211030385
Abstract: Purpose: It remains controversial whether neuronal damage and synaptic reorganization found in some forms of epilepsy are the result of an initial injury and potentially contributory to the epileptic condition or are the cumulative effect… read more here.
Keywords: seizure; progressive neuronal; epilepsy; kindled rats ... See more keywords
Xenon treatment after severe traumatic brain injury improves locomotor outcome, reduces acute neuronal loss and enhances early beneficial neuroinflammation: a randomized, blinded, controlled animal study
Sign Up to like & getrecommendations! Published in 2020 at "Critical Care"
DOI: 10.1186/s13054-020-03373-9
Abstract: Background Traumatic brain injury (TBI) is a major cause of morbidity and mortality, but there are no clinically proven treatments that specifically target neuronal loss and secondary injury development following TBI. In this study, we… read more here.
Keywords: neuronal loss; xenon; treatment; brain ... See more keywords