Neuronal Mitophagy: Lessons from a Pathway Linked to Parkinson’s Disease
Sign Up to like & getrecommendations! Published in 2019 at "Neurotoxicity Research"
DOI: 10.1007/s12640-019-00060-8
Abstract: Neurons are specialized cells with complex and extended architecture and high energy requirements. Energy in the form of adenosine triphosphate, produced essentially by mitochondrial respiration, is necessary to preserve neuronal morphology, maintain resting potential, fire… read more here.
Keywords: mitophagy lessons; neuronal mitophagy; lessons pathway; pink1 parkin ... See more keywords
A synergized machine learning plus cross-species wet-lab validation approach identifies neuronal mitophagy inducers inhibiting Alzheimer disease
Sign Up to like & getrecommendations! Published in 2022 at "Autophagy"
DOI: 10.1080/15548627.2022.2031382
Abstract: ABSTRACT Failed recognition and clearance of damaged mitochondria contributes to memory loss as well as Aβ and MAPT/Tau pathologies in Alzheimer disease (AD), for which there is an unmet therapeutic need. Restoring mitophagy to eliminate… read more here.
Keywords: alzheimer disease; cross species; machine learning; mitophagy ... See more keywords