P85 regulates neuronal migration through affecting neuronal morphology during mouse corticogenesis
Sign Up to like & getrecommendations! Published in 2017 at "Cell and Tissue Research"
DOI: 10.1007/s00441-017-2707-8
Abstract: In mammalian developing embryonic cortex, projection neurons migrate from the ventricular zone to the cortical plate, guided by radial glial cells with a transformation between bipolar and multipolar morphology. Previous studies have demonstrated that the… read more here.
Keywords: morphology mouse; neuronal morphology; p85; neuronal migration ... See more keywords
Huntingtin-Mediated Multipolar-Bipolar Transition of Newborn Cortical Neurons Is Critical for Their Postnatal Neuronal Morphology
Sign Up to like & getrecommendations! Published in 2017 at "Neuron"
DOI: 10.1016/j.neuron.2016.11.035
Abstract: In the developing cortex, projection neurons undergo multipolar-bipolar transition, radial-directed migration, and maturation. The contribution of these developmental steps to the structure of the adult cortex is not completely understood. Here, we report that huntingtin… read more here.
Keywords: htt; multipolar bipolar; projection neurons; neuronal morphology ... See more keywords
Weighing the Evidence in Peters’ Rule: Does Neuronal Morphology Predict Connectivity?
Sign Up to like & getrecommendations! Published in 2017 at "Trends in Neurosciences"
DOI: 10.1016/j.tins.2016.11.007
Abstract: Although the importance of network connectivity is increasingly recognized, identifying synapses remains challenging relative to the routine characterization of neuronal morphology. Thus, researchers frequently employ axon-dendrite colocations as proxies of potential connections. This putative equivalence,… read more here.
Keywords: connectivity; neuronal morphology; peters rule; evidence peters ... See more keywords
Pten heterozygosity restores neuronal morphology in fragile X syndrome mice
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2109448119
Abstract: Significance Phosphatase and tensin homolog protein (PTEN) and fragile X mental retardation protein (FMRP) play a vital role in neuronal development and function. This work provides new evidence for the genetic interaction of Pten and… read more here.
Keywords: heterozygosity restores; pten heterozygosity; neuronal morphology; pten fmr1 ... See more keywords
NeuroMorphoVis: a collaborative framework for analysis and visualization of neuronal morphology skeletons reconstructed from microscopy stacks
Sign Up to like & getrecommendations! Published in 2018 at "Bioinformatics"
DOI: 10.1093/bioinformatics/bty231
Abstract: Motivation From image stacks to computational models, processing digital representations of neuronal morphologies is essential to neuroscientific research. Workflows involve various techniques and tools, leading in certain cases to convoluted and fragmented pipelines. The existence… read more here.
Keywords: framework; neuronal morphology; analysis visualization; microscopy ... See more keywords
Neuronal morphology alterations in autism and possible role of oxytocin
Sign Up to like & getrecommendations! Published in 2019 at "Endocrine Regulations"
DOI: 10.2478/enr-2019-0006
Abstract: Abstract Current understanding of the neuroanatomical abnormalities in autism includes gross anatomical changes in several brain areas and microstructural alterations in neuronal cells as well. There are many controversies in the interpretation of the imaging… read more here.
Keywords: autism; brain; neuronal morphology; role oxytocin ... See more keywords
The Interactome of Palmitoyl-Protein Thioesterase 1 (PPT1) Affects Neuronal Morphology and Function
Sign Up to like & getrecommendations! Published in 2019 at "Frontiers in Cellular Neuroscience"
DOI: 10.3389/fncel.2019.00092
Abstract: Palmitoyl-protein thioesterase 1 (PPT1) is a depalmitoylation enzyme that is mutated in cases of neuronal ceroid lipofuscinosis (NCL). The hallmarks of the disease include progressive neurodegeneration and blindness, as well as seizures. In the current… read more here.
Keywords: palmitoyl protein; ppt1; protein thioesterase; thioesterase ppt1 ... See more keywords
Neuronal Morphology and Synapse Count in the Nematode Worm
Sign Up to like & getrecommendations! Published in 2019 at "Frontiers in Computational Neuroscience"
DOI: 10.3389/fncom.2019.00074
Abstract: The somatic nervous system of the nematode worm Caenorhabditis elegans is a model for understanding the physical characteristics of the neurons and their interconnections. Its neurons show high variation in morphological attributes. This study investigates… read more here.
Keywords: morphology synapse; morphology; neuronal morphology; nematode worm ... See more keywords
Lack of APLP1 leads to subtle alterations in neuronal morphology but does not affect learning and memory
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Molecular Neuroscience"
DOI: 10.3389/fnmol.2022.1028836
Abstract: The amyloid precursor protein APP plays a crucial role in Alzheimer pathogenesis. Its physiological functions, however, are only beginning to be unraveled. APP belongs to a small gene family, including besides APP the closely related… read more here.
Keywords: neuronal morphology; learning memory; lack aplp1; subtle alterations ... See more keywords
A Neuronal Morphology Classification Approach Based on Locally Cumulative Connected Deep Neural Networks
Sign Up to like & getrecommendations! Published in 2019 at "Applied Sciences"
DOI: 10.3390/app9183876
Abstract: Neurons are the basic building and computational units of the nervous system, and have complex and diverse spatial geometric structures. By solving the neuronal classification problem, we can further understand the characteristics of neurons and… read more here.
Keywords: classification; morphology classification; neuronal morphology; approach ... See more keywords
miR-196a Enhances Neuronal Morphology through Suppressing RANBP10 to Provide Neuroprotection in Huntington's Disease
Sign Up to like & getrecommendations! Published in 2017 at "Theranostics"
DOI: 10.7150/thno.18813
Abstract: MicroRNAs (miRNAs) play important roles in several neurobiological processes, including the development and progression of diseases. Previously, we identified that one specific miRNA, miR-196a, provides neuroprotective effects on Huntington's disease (HD), although the detailed mechanism… read more here.
Keywords: enhances neuronal; huntington disease; mir 196a; neuronal morphology ... See more keywords