Computational Inference of Synaptic Polarities in Neuronal Networks
Sign Up to like & getrecommendations! Published in 2022 at "Advanced Science"
DOI: 10.1002/advs.202104906
Abstract: Synaptic polarity, that is, whether synapses are inhibitory (−) or excitatory (+), is challenging to map, despite being a key to understand brain function. Here, synaptic polarity is inferred computationally considering three experimental scenarios, depending… read more here.
Keywords: synaptic polarity; polarities neuronal; inference synaptic; computational inference ... See more keywords
Optogenetic manipulation of astrocytes from synapses to neuronal networks: A potential therapeutic strategy for neurodegenerative diseases
Sign Up to like & getrecommendations! Published in 2019 at "Glia"
DOI: 10.1002/glia.23693
Abstract: Astrocytes are the most widespread and heterogeneous glial cells in the central nervous system and key regulators for brain development. They are capable of receiving neurotransmitters produced by synaptic activities and regulating synaptic functions by… read more here.
Keywords: therapeutic strategy; neurodegenerative diseases; potential therapeutic; optogenetic manipulation ... See more keywords
Inhibitory control in neuronal networks relies on the extracellular matrix integrity
Sign Up to like & getrecommendations! Published in 2021 at "Cellular and Molecular Life Sciences"
DOI: 10.1007/s00018-021-03861-3
Abstract: Graphic abstract Inhibitory control is essential for the regulation of neuronal network activity, where excitatory and inhibitory synapses can act synergistically, reciprocally, and antagonistically. Sustained excitation-inhibition (E-I) balance, therefore, relies on the orchestrated adjustment of… read more here.
Keywords: synapse; inhibitory; inhibitory control; ecm ... See more keywords
Pattern control of external electromagnetic stimulation to neuronal networks
Sign Up to like & getrecommendations! Published in 2020 at "Nonlinear Dynamics"
DOI: 10.1007/s11071-020-06076-6
Abstract: The application of external electromagnetic stimulation to regulate the electrophysiological activities of specific brain regions can provide an ideal control or treatment scheme for some non-organic mental diseases. To further explore the effectiveness of electromagnetic… read more here.
Keywords: pattern control; stimulation; control external; electromagnetic stimulation ... See more keywords
Mapping functional connectivity of bursting neuronal networks
Sign Up to like & getrecommendations! Published in 2017 at "Applied Network Science"
DOI: 10.1007/s41109-017-0037-0
Abstract: Using single-cell laser scanning photostimulation (LSPS) combined with broad-field calcium imaging, we measured the functional connectivity of neuronal cultures before and after the developmental appearance of network bursting. From these data, network properties were determined… read more here.
Keywords: network; connectivity bursting; mapping functional; neuronal networks ... See more keywords
Once upon a (slow) time in the land of recurrent neuronal networks…
Sign Up to like & getrecommendations! Published in 2017 at "Current Opinion in Neurobiology"
DOI: 10.1016/j.conb.2017.07.003
Abstract: The brain must both react quickly to new inputs as well as store a memory of past activity. This requires biology that operates over a vast range of time scales. Fast time scales are determined… read more here.
Keywords: time land; time scales; time; upon slow ... See more keywords
Enantioselectivity of 2,2',3,5',6-Pentachlorobiphenyl (PCB 95) Atropisomers toward Ryanodine Receptors (RyRs) and Their Influences on Hippocampal Neuronal Networks.
Sign Up to like & getrecommendations! Published in 2017 at "Environmental science & technology"
DOI: 10.1021/acs.est.7b04446
Abstract: Nineteen ortho-substituted PCBs are chiral and found enantioselectively enriched in ecosystems. Their differential actions on biological targets are not understood. PCB 95 (2,2',3,5',6-pentachlorobiphenyl), a chiral PCB of current environmental relevance, is among the most potent… read more here.
Keywords: hippocampal neuronal; pcb; ryanodine receptors; enantioselectivity pentachlorobiphenyl ... See more keywords
In Vitro Development of Human iPSC-Derived Functional Neuronal Networks on Laser-Fabricated 3D Scaffolds.
Sign Up to like & getrecommendations! Published in 2021 at "ACS applied materials & interfaces"
DOI: 10.1021/acsami.0c16616
Abstract: Neural progenitor cells generated from human induced pluripotent stem cells (hiPSCs) are the forefront of ″brain-on-chip″ investigations. Viable and functional hiPSC-derived neuronal networks are shaping powerful in vitro models for evaluating the normal and abnormal… read more here.
Keywords: neuronal networks; vitro development; human ipsc; ipsc derived ... See more keywords
Inflammatory Molecules Released by Mechanically Injured Astrocytes Trigger Presynaptic Loss in Cortical Neuronal Networks.
Sign Up to like & getrecommendations! Published in 2021 at "ACS chemical neuroscience"
DOI: 10.1021/acschemneuro.1c00488
Abstract: Deformation, compression, or stretching of brain tissues cause diffuse axonal injury (DAI) and induce structural and functional alterations of astrocytes, the most abundant cell type in the brain. To gain further insight into the role… read more here.
Keywords: cortical neuronal; released mechanically; mechanically activated; injured astrocytes ... See more keywords
A simplified protocol for differentiation of electrophysiologically mature neuronal networks from human induced pluripotent stem cells
Sign Up to like & getrecommendations! Published in 2018 at "Molecular Psychiatry"
DOI: 10.1038/mp.2017.56
Abstract: Progress in elucidating the molecular and cellular pathophysiology of neuropsychiatric disorders has been hindered by the limited availability of living human brain tissue. The emergence of induced pluripotent stem cells (iPSCs) has offered a unique… read more here.
Keywords: pluripotent stem; electrophysiologically mature; induced pluripotent; stem cells ... See more keywords
Micro-connectomics: probing the organization of neuronal networks at the cellular scale
Sign Up to like & getrecommendations! Published in 2017 at "Nature Reviews Neuroscience"
DOI: 10.1038/nrn.2016.182
Abstract: Defining the organizational principles of neuronal networks at the cellular scale, or micro-connectomics, is a key challenge of modern neuroscience. In this Review, we focus on graph theoretical parameters of micro-connectome topology, often informed by… read more here.
Keywords: networks cellular; connectomics; micro connectomics; cellular scale ... See more keywords