Potentiation of a neuronal nicotinic receptor via pseudo-agonist site
Sign Up to like & getrecommendations! Published in 2019 at "Cellular and Molecular Life Sciences"
DOI: 10.1007/s00018-018-2993-7
Abstract: Neuronal nicotinic receptors containing α4 and β2 subunits assemble in two pentameric stoichiometries, (α4)3(β2)2 and (α4)2(β2)3, each with distinct pharmacological signatures; (α4)3(β2)2 receptors are strongly potentiated by the drug NS9283, whereas (α4)2(β2)3 receptors are unaffected.… read more here.
Keywords: neuronal nicotinic; pseudo agonist; agonist site; receptor ... See more keywords
Development of 11C-Labeled ASEM Analogues for the Detection of Neuronal Nicotinic Acetylcholine Receptors (α7-nAChR)
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DOI: 10.1021/acschemneuro.1c00730
Abstract: The homo-pentameric alpha 7 receptor is one of the major types of neuronal nicotinic acetylcholine receptors (α7-nAChRs) related to cognition, memory formation, and attention processing. The mapping of α7-nAChRs by PET pulls a lot of… read more here.
Keywords: acetylcholine receptors; asem analogues; development; nicotinic acetylcholine ... See more keywords
An Overview on the Effect of Neonicotinoid Insecticides on Mammalian Cholinergic Functions through the Activation of Neuronal Nicotinic Acetylcholine Receptors
Sign Up to like & getrecommendations! Published in 2020 at "International Journal of Environmental Research and Public Health"
DOI: 10.3390/ijerph17093222
Abstract: Neonicotinoid insecticides are used worldwide and have been demonstrated as toxic to beneficial insects such as honeybees. Their effectiveness is predominantly attributed to their high affinity for insect neuronal nicotinic acetylcholine receptors (nAChRs). Mammalian neuronal… read more here.
Keywords: neonicotinoid insecticides; acetylcholine receptors; insecticides mammalian; nicotinic acetylcholine ... See more keywords