Neuronal population models reveal specific linear conductance controllers sufficient to rescue preclinical disease phenotypes
Sign Up to like & getrecommendations! Published in 2021 at "iScience"
DOI: 10.1016/j.isci.2021.103279
Abstract: Summary Preclinical drug candidates are screened for their ability to ameliorate in vitro neuronal electrophysiology, and go/no-go decisions progress drugs to clinical trials based on population means across cells and animals. However, these measures do… read more here.
Keywords: models reveal; population models; disease; drug ... See more keywords
Neuronal population correlates of target selection and distractor filtering
Sign Up to like & getrecommendations! Published in 2020 at "NeuroImage"
DOI: 10.1016/j.neuroimage.2020.116517
Abstract: Frontal Eye Field (FEF) neurons discriminate between relevant and irrelevant visual stimuli and their response magnitude predicts conscious perception. How this is reflected in the spatial representation of a visual stimulus at the neuronal population… read more here.
Keywords: correlates target; distractor; population; population correlates ... See more keywords
Bifurcation of the neuronal population dynamics of the modified theta model: Transition to macroscopic gamma oscillation
Sign Up to like & getrecommendations! Published in 2020 at "Physica D: Nonlinear Phenomena"
DOI: 10.1016/j.physd.2020.132789
Abstract: Abstract Interactions of inhibitory neurons produce gamma oscillations (30–80 Hz) in the local field potential, which is known to be involved in functions such as cognition and attention. In this study, the modified theta model… read more here.
Keywords: theta model; gamma oscillation; model; modified theta ... See more keywords
Finding Kinematics-Driven Latent Neural States From Neuronal Population Activity for Motor Decoding
Sign Up to like & getrecommendations! Published in 2021 at "IEEE Transactions on Neural Systems and Rehabilitation Engineering"
DOI: 10.1109/tnsre.2021.3114367
Abstract: While intracortical brain–machine interfaces (BMIs) demonstrate feasibility to restore mobility to people with paralysis, it is still challenging to maintain high-performance decoding in clinical BMIs. One of the main obstacles for high-performance BMI is the… read more here.
Keywords: latent neural; neural states; neuronal population; population activity ... See more keywords
The neuronal population is the key unit
Sign Up to like & getrecommendations! Published in 2018 at "Science"
DOI: 10.1126/science.359.6374.407-q
Abstract: Neuroscience The responses of pairs of neurons to repeated presentations of the same stimulus are typically correlated, and an identical neuronal population can perform many functions. This suggests that the relevant units of computation are… read more here.
Keywords: key unit; population activity; population key; population ... See more keywords
Identification of a neuronal population in the telencephalon essential for fear conditioning in zebrafish
Sign Up to like & getrecommendations! Published in 2018 at "BMC Biology"
DOI: 10.1186/s12915-018-0502-y
Abstract: BackgroundFear conditioning is a form of learning essential for animal survival and used as a behavioral paradigm to study the mechanisms of learning and memory. In mammals, the amygdala plays a crucial role in fear… read more here.
Keywords: fear; fear conditioning; essential fear; telencephalon ... See more keywords
Striatal D1 Dopamine Neuronal Population Dynamics in a Rat Model of Levodopa-Induced Dyskinesia
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Aging Neuroscience"
DOI: 10.3389/fnagi.2022.783893
Abstract: Background The pathophysiology of levodopa-induced dyskinesia (LID) in Parkinson’s disease (PD) is not well understood. Experimental data from numerous investigations support the idea that aberrant activity of D1 dopamine receptor-positive medium spiny neurons in the… read more here.
Keywords: induced dyskinesia; neuronal population; lid rats; levodopa ... See more keywords
Daily two-photon neuronal population imaging with targeted single-cell electrophysiology and subcellular imaging in auditory cortex of behaving mice
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Cellular Neuroscience"
DOI: 10.3389/fncel.2023.1142267
Abstract: Quantitative and mechanistic understanding of learning and long-term memory at the level of single neurons in living brains require highly demanding techniques. A specific need is to precisely label one cell whose firing output property… read more here.
Keywords: cell; two photon; neuronal population; population ... See more keywords