CCR5 Activation Promotes NLRP1-Dependent Neuronal Pyroptosis via CCR5/PKA/CREB Pathway After Intracerebral Hemorrhage
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DOI: 10.1161/strokeaha.120.033285
Abstract: Supplemental Digital Content is available in the text. Background and Purpose: Neuronal pyroptosis is a type of regulated cell death triggered by proinflammatory signals. CCR5 (C-C chemokine receptor 5)-mediated inflammation is involved in the pathology… read more here.
Keywords: neuronal pyroptosis; pka creb; ccr5;
TAK1 mediates neuronal pyroptosis in early brain injury after subarachnoid hemorrhage
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DOI: 10.1186/s12974-021-02226-8
Abstract: Background Innate immunity can facilitate early brain injury (EBI) following subarachnoid hemorrhage (SAH). Numerous studies suggest that pyroptosis could exacerbate extracellular immune responses by promoting secretion of inflammatory cytokines. Transforming growth factor-β-activated kinase 1 (TAK1)… read more here.
Keywords: tak1; early brain; neuronal pyroptosis; brain ... See more keywords
Schisandrin Inhibits NLRP1 Inflammasome-Mediated Neuronal Pyroptosis in Mouse Models of Alzheimer’s Disease
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DOI: 10.2147/ndt.s279147
Abstract: Background In recent years, schisandrin (SCH) was proved to improve Alzheimer's Disease (AD). The aim of our study is to explore the effect of SCH on neuronal pyroptosis in the disease. Methods A Morris water… read more here.
Keywords: nlrp1 inflammasome; neuronal apoptosis; neuronal pyroptosis; pyroptosis ... See more keywords
Curcumin Alleviates Cerebral Ischemia-reperfusion Injury by Inhibiting NLRP1-dependent Neuronal Pyroptosis.
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DOI: 10.2174/1567202618666210607150140
Abstract: BACKGROUND Cerebral ischemia-reperfusion injury is caused by a blood reperfusion injury in the ischemic brain and usually occurs in the treatment stage of ischemic disease, which can aggravate brain tissue injury. OBJECTIVE Curcumin was reported… read more here.
Keywords: cerebral ischemia; reperfusion injury; ischemia reperfusion; neuronal pyroptosis ... See more keywords
Inhibition of neutrophil extracellular trap formation attenuates NLRP1-dependent neuronal pyroptosis via STING/IRE1α pathway after traumatic brain injury in mice
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DOI: 10.3389/fimmu.2023.1125759
Abstract: Introduction Increased neutrophil extracellular trap (NET) formation has been reported to be associated with cerebrovascular dysfunction and neurological deficits in traumatic brain injury (TBI). However, the biological function and underlying mechanisms of NETs in TBI-induced… read more here.
Keywords: tbi; brain; neuronal pyroptosis; mice ... See more keywords
Modafinil Reduces Neuronal Pyroptosis and Cognitive Decline After Sleep Deprivation
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DOI: 10.3389/fnins.2022.816752
Abstract: Sleep deprivation (SD) induces systemic inflammation that promotes neuronal pyroptosis. The purpose of this study was to investigate the effect of an antioxidant modafinil on neuronal pyroptosis and cognitive decline following SD. Using a mouse… read more here.
Keywords: sleep deprivation; pyroptosis; neuronal pyroptosis; pyroptosis cognitive ... See more keywords