DDX3X Aggravates Neuronal Pyroptosis and Inhibits Autophagy via NLRP3 Inflammasome After Experimental Subarachnoid Hemorrhage
Sign Up to like & getrecommendations! Published in 2025 at "Molecular Neurobiology"
DOI: 10.1007/s12035-025-05195-8
Abstract: Neuronal cell death is considered the symbol of early brain injury after subarachnoid hemorrhage (SAH), but the mechanism was still unclear. DDX3X, a member of the DEAD-box helicase family, has a major effect on immune… read more here.
Keywords: neuronal pyroptosis; ddx3x; via nlrp3; nlrp3 inflammasome ... See more keywords
Electroacupuncture reduces neuroinflammation and neuronal pyroptosis via downregulating Neat1 in rats after stroke
Sign Up to like & getrecommendations! Published in 2025 at "Stroke and Vascular Neurology"
DOI: 10.1136/svn-2024-003964
Abstract: Background We investigated the potential contribution of the lncRNA Neat1 to the therapeutic efficacy of electroacupuncture (EA) after ischaemic stroke. Methods EA stimulation was used to treat cerebral ischaemia/reperfusion injury (CIRI) in the rat model.… read more here.
Keywords: electroacupuncture reduces; neuronal pyroptosis; neat1 overexpression; pyroptosis ... See more keywords
G Protein-Coupled Receptor 30 Attenuates Neuronal Pyroptosis Induced by Subarachnoid Hemorrhage
Sign Up to like & getrecommendations! Published in 2025 at "Mediators of Inflammation"
DOI: 10.1155/mi/3585885
Abstract: Background: Pyroptosis is implicated as a pathogenic mechanism in early brain injury (EBI) after subarachnoid hemorrhage (SAH). This study aimed to investigate the regulatory role of G protein-coupled receptor 30 (GPR30) in neuronal pyroptosis during… read more here.
Keywords: receptor; neuronal pyroptosis; pyroptosis; subarachnoid hemorrhage ... See more keywords
CCR5 Activation Promotes NLRP1-Dependent Neuronal Pyroptosis via CCR5/PKA/CREB Pathway After Intracerebral Hemorrhage
Sign Up to like & getrecommendations! Published in 2021 at "Stroke"
DOI: 10.1161/strokeaha.120.033285
Abstract: Supplemental Digital Content is available in the text. Background and Purpose: Neuronal pyroptosis is a type of regulated cell death triggered by proinflammatory signals. CCR5 (C-C chemokine receptor 5)-mediated inflammation is involved in the pathology… read more here.
Keywords: neuronal pyroptosis; pka creb; ccr5;
TAK1 mediates neuronal pyroptosis in early brain injury after subarachnoid hemorrhage
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Neuroinflammation"
DOI: 10.1186/s12974-021-02226-8
Abstract: Background Innate immunity can facilitate early brain injury (EBI) following subarachnoid hemorrhage (SAH). Numerous studies suggest that pyroptosis could exacerbate extracellular immune responses by promoting secretion of inflammatory cytokines. Transforming growth factor-β-activated kinase 1 (TAK1)… read more here.
Keywords: tak1; early brain; neuronal pyroptosis; brain ... See more keywords
LARP7 protects against ischemic brain injury by modulating NLRP3 deacetylation to suppress neuronal pyroptosis.
Sign Up to like & getrecommendations! Published in 2025 at "Journal of neuroinflammation"
DOI: 10.1186/s12974-025-03649-3
Abstract: Ischemic stroke is a leading cause of morbidity and mortality worldwide, yet available therapeutic strategies remain limited. La ribonucleoprotein domain family member 7 (LARP7), a critical regulator of RNA stability and transcriptional control, participates in… read more here.
Keywords: nlrp3 deacetylation; neuronal pyroptosis; larp7; ischemic stroke ... See more keywords
Schisandrin Inhibits NLRP1 Inflammasome-Mediated Neuronal Pyroptosis in Mouse Models of Alzheimer’s Disease
Sign Up to like & getrecommendations! Published in 2021 at "Neuropsychiatric Disease and Treatment"
DOI: 10.2147/ndt.s279147
Abstract: Background In recent years, schisandrin (SCH) was proved to improve Alzheimer's Disease (AD). The aim of our study is to explore the effect of SCH on neuronal pyroptosis in the disease. Methods A Morris water… read more here.
Keywords: nlrp1 inflammasome; neuronal apoptosis; neuronal pyroptosis; pyroptosis ... See more keywords
Curcumin Alleviates Cerebral Ischemia-reperfusion Injury by Inhibiting NLRP1-dependent Neuronal Pyroptosis.
Sign Up to like & getrecommendations! Published in 2021 at "Current neurovascular research"
DOI: 10.2174/1567202618666210607150140
Abstract: BACKGROUND Cerebral ischemia-reperfusion injury is caused by a blood reperfusion injury in the ischemic brain and usually occurs in the treatment stage of ischemic disease, which can aggravate brain tissue injury. OBJECTIVE Curcumin was reported… read more here.
Keywords: cerebral ischemia; reperfusion injury; ischemia reperfusion; neuronal pyroptosis ... See more keywords
Inhibition of neutrophil extracellular trap formation attenuates NLRP1-dependent neuronal pyroptosis via STING/IRE1α pathway after traumatic brain injury in mice
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2023.1125759
Abstract: Introduction Increased neutrophil extracellular trap (NET) formation has been reported to be associated with cerebrovascular dysfunction and neurological deficits in traumatic brain injury (TBI). However, the biological function and underlying mechanisms of NETs in TBI-induced… read more here.
Keywords: tbi; brain; neuronal pyroptosis; mice ... See more keywords
Modafinil Reduces Neuronal Pyroptosis and Cognitive Decline After Sleep Deprivation
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Neuroscience"
DOI: 10.3389/fnins.2022.816752
Abstract: Sleep deprivation (SD) induces systemic inflammation that promotes neuronal pyroptosis. The purpose of this study was to investigate the effect of an antioxidant modafinil on neuronal pyroptosis and cognitive decline following SD. Using a mouse… read more here.
Keywords: sleep deprivation; pyroptosis; neuronal pyroptosis; pyroptosis cognitive ... See more keywords