Isolation and Neuronal Reprogramming of Mouse Embryonic Fibroblasts.
Sign Up to like & getrecommendations! Published in 2021 at "Methods in molecular biology"
DOI: 10.1007/978-1-0716-1601-7_1
Abstract: Forced expression of specific neuronal transcription factors in mouse embryonic fibroblasts (MEFs) can lead to their direct conversion into functional neurons. Direct neuronal reprogramming has become a powerful tool to characterize individual factors and molecular… read more here.
Keywords: isolation neuronal; embryonic fibroblasts; mouse embryonic; reprogramming ... See more keywords
Strategic Application of Epigenetic Regulators for Efficient Neuronal Reprogramming of Human Fibroblasts
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Stem Cells"
DOI: 10.15283/ijsc22183
Abstract: Background and Objectives Cellular reprogramming in regenerative medicine holds great promise for treating patients with neurological disorders. In this regard, small molecule-mediated cellular conversion has attracted special attention because of its ease of reproducibility, applicability,… read more here.
Keywords: application; conversion; neuronal reprogramming; like cells ... See more keywords
Application of Small Molecules in the Central Nervous System Direct Neuronal Reprogramming
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Bioengineering and Biotechnology"
DOI: 10.3389/fbioe.2022.799152
Abstract: The lack of regenerative capacity of neurons leads to poor prognoses for some neurological disorders. The use of small molecules to directly reprogram somatic cells into neurons provides a new therapeutic strategy for neurological diseases.… read more here.
Keywords: molecules central; central nervous; neuronal reprogramming; small molecules ... See more keywords
Direct Neuronal Reprogramming: Bridging the Gap Between Basic Science and Clinical Application
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2021.681087
Abstract: Direct neuronal reprogramming is an innovative new technology that involves the conversion of somatic cells to induced neurons (iNs) without passing through a pluripotent state. The capacity to make new neurons in the brain, which… read more here.
Keywords: reprogramming bridging; direct neuronal; bridging gap; brain ... See more keywords
Direct Neuronal Reprogramming Reveals Unknown Functions for Known Transcription Factors
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DOI: 10.3389/fnins.2019.00283
Abstract: In recent years, the need to derive sources of specialized cell types to be employed for cell replacement therapies and modeling studies has triggered a fast acceleration of novel cell reprogramming methods. In particular, in… read more here.
Keywords: transcription factors; direct neuronal; reprogramming reveals; neuronal reprogramming ... See more keywords
Neuronal Reprogramming for Tissue Repair and Neuroregeneration
Sign Up to like & getrecommendations! Published in 2020 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms21124273
Abstract: Stem cell and cell reprogramming technology represent a rapidly growing field in regenerative medicine. A number of novel neural reprogramming methods have been established, using pluripotent stem cells (PSCs) or direct reprogramming, to efficiently derive… read more here.
Keywords: medicine; tissue repair; reprogramming tissue; neuronal reprogramming ... See more keywords