Organotypic slice culture model demonstrates inter-neuronal spreading of alpha-synuclein aggregates
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DOI: 10.1186/s40478-019-0865-5
Abstract: Here we describe the use of an organotypic hippocampal slice model for studying α-synuclein aggregation and inter-neuronal spreading initiated by microinjection of pre-formed α-synuclein fibrils (PFFs). PFF injection at dentate gyrus (DG) templates the formation… read more here.
Keywords: synuclein; model; neuronal spreading; inter neuronal ... See more keywords