Recent advances in our understanding of central and peripheral nervous system progenitors.
Sign Up to like & getrecommendations! Published in 2019 at "Current opinion in cell biology"
DOI: 10.1016/j.ceb.2019.07.003
Abstract: Several decades of intense research provided us with a grand framework describing the emergence of neurons in central (CNS) and peripheral (PNS) nervous systems. However, the specifics of molecular events and lineage control leading to… read more here.
Keywords: understanding central; neuronal subtypes; advances understanding; peripheral nervous ... See more keywords
A spatially-resolved transcriptional atlas of the murine dorsal pons at single-cell resolution
Sign Up to like & getrecommendations! Published in 2024 at "Nature Communications"
DOI: 10.1038/s41467-024-45907-7
Abstract: The “dorsal pons”, or “dorsal pontine tegmentum” (dPnTg), is part of the brainstem. It is a complex, densely packed region whose nuclei are involved in regulating many vital functions. Notable among them are the parabrachial… read more here.
Keywords: transcriptional atlas; spatially resolved; resolved transcriptional; atlas murine ... See more keywords
Specification of neuronal subtypes in the spiral ganglion begins prior to birth in the mouse
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2203935119
Abstract: Significance Spiral Ganglion neurons (SGNs) are responsible for relaying complex sound information from the cochlea to the auditory brainstem, and their loss contributes to age-related and acquired hearing loss. Physiological, anatomical, and molecular approaches have… read more here.
Keywords: ganglion; subtypes spiral; spiral ganglion; specification neuronal ... See more keywords
RNA extraction from sorted neuronal subtypes
Sign Up to like & getrecommendations! Published in 2017 at "BioTechniques"
DOI: 10.2144/000114499
Abstract: Protocol Summary Efficient isolation of specific, intact, living neurons from the adult brain is problematic due to the complex nature of the extracellular matrix consolidating the neuronal network... read more here.
Keywords: rna extraction; sorted neuronal; neuronal subtypes; extraction sorted ... See more keywords
Critical contributions of neuronal subtypes to pediatric drug-resistant focal dysplasia
Sign Up to like & getrecommendations! Published in 2025 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2025.1566137
Abstract: Approximately 75% of epilepsy cases emerge in childhood, and 10%–30% of these pediatric epilepsy cases are resistant to standard drug therapies; however, the underlying causes of resistance remain poorly understood. Focal cortical dysplasia (FCD) is… read more here.
Keywords: dysplasia; drug; contributions neuronal; critical contributions ... See more keywords
Reduced Insulin Signaling Targeted to Serotonergic Neurons but Not Other Neuronal Subtypes Extends Lifespan in Drosophila melanogaster
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Aging Neuroscience"
DOI: 10.3389/fnagi.2022.893444
Abstract: Reduced Insulin/IGF-like signaling (IIS) plays an evolutionarily conserved role in improving longevity and some measures of health-span in model organisms. Recent studies, however, have found a disconnection between lifespan extension and behavioral health-span. We have… read more here.
Keywords: lifespan; senescence; reduced insulin; serotonergic neurons ... See more keywords