Monocyte NLRP3-IL-1β Hyperactivation Mediates Neuronal and Synaptic Dysfunction in Perioperative Neurocognitive Disorder.
Sign Up to like & getrecommendations! Published in 2022 at "Advanced science"
DOI: 10.1002/advs.202104106
Abstract: Perioperative neurocognitive disorder may develop in vulnerable patients following major operation. While neuroinflammation is linked to the cognitive effects of surgery, how surgery and immune signaling modulate neuronal circuits, leading to learning and memory impairment… read more here.
Keywords: surgery; perioperative neurocognitive; neurocognitive disorder; neuronal synaptic ... See more keywords
Endocannabinoid degradation inhibitors ameliorate neuronal and synaptic alterations following traumatic brain injury.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of neurophysiology"
DOI: 10.1152/jn.00570.2019
Abstract: Our previous work showed that lateral fluid percussion injury to the sensorimotor cortex (SMC) of anesthetized rats increased neuronal synaptic hyperexcitability in layer 5 (L5) neurons in ex vivo brain slices 10 days post-injury. Furthermore,… read more here.
Keywords: degradation; neuronal synaptic; degradation inhibitors; brain ... See more keywords
Neuronal and Synaptic Plasticity in the Visual Thalamus in Mouse Models of Glaucoma
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Cellular Neuroscience"
DOI: 10.3389/fncel.2020.626056
Abstract: Homeostatic plasticity plays important role in regulating synaptic and intrinsic neuronal function to stabilize output following perturbations to circuit activity. In glaucoma, a neurodegenerative disease of the visual system commonly associated with elevated intraocular pressure… read more here.
Keywords: models glaucoma; mouse models; neuronal synaptic; functional changes ... See more keywords