Microglial activation and the nitric oxide/cGMP/PKG pathway underlie enhanced neuronal vulnerability to mitochondrial dysfunction in experimental multiple sclerosis
Sign Up to like & getrecommendations! Published in 2018 at "Neurobiology of Disease"
DOI: 10.1016/j.nbd.2018.01.002
Abstract: During multiple sclerosis (MS), a close link has been demonstrated to occur between inflammation and neuro-axonal degeneration, leading to the hypothesis that immune mechanisms may promote neurodegeneration, leading to irreversible disease progression. Energy deficits and… read more here.
Keywords: vulnerability; multiple sclerosis; mitochondrial dysfunction; nitric oxide ... See more keywords
Deferoxamine deconditioning increases neuronal vulnerability to hemoglobin.
Sign Up to like & getrecommendations! Published in 2020 at "Experimental cell research"
DOI: 10.1016/j.yexcr.2020.111926
Abstract: Concomitant treatment with deferoxamine (DFO) protects neural cells from iron and heme-mediated oxidative injury, but also disrupts cell responses to iron loading that may be protective. We hypothesized that DFO treatment and withdrawal would subsequently… read more here.
Keywords: hemoglobin; heme; deferoxamine; vulnerability hemoglobin ... See more keywords
Parvalbumin Interneurons Shape Neuronal Vulnerability in Blunt TBI.
Sign Up to like & getrecommendations! Published in 2019 at "Cerebral cortex"
DOI: 10.1093/cercor/bhy139
Abstract: Excessive excitation has been hypothesized to subsume a significant part of the acute damage occurring after traumatic brain injury (TBI). However, reduced neuronal excitability, loss of neuronal firing, and a disturbed excitation/inhibition balance have been… read more here.
Keywords: parvalbumin interneurons; inhibition; tbi; principal neurons ... See more keywords
Dissecting the neuronal vulnerability underpinning Alpers’ syndrome: a clinical and neuropathological study
Sign Up to like & getrecommendations! Published in 2019 at "Brain Pathology"
DOI: 10.1111/bpa.12640
Abstract: Alpers’ syndrome is an early‐onset neurodegenerative disorder often caused by biallelic pathogenic variants in the gene encoding the catalytic subunit of polymerase‐gamma (POLG) which is essential for mitochondrial DNA (mtDNA) replication. Alpers’ syndrome is characterized… read more here.
Keywords: study; pathology; neuropathological study; dissecting neuronal ... See more keywords
G9a dictates neuronal vulnerability to inflammatory stress via transcriptional control of ferroptosis
Sign Up to like & getrecommendations! Published in 2022 at "Science Advances"
DOI: 10.1126/sciadv.abm5500
Abstract: Neuroinflammation leads to neuronal stress responses that contribute to neuronal dysfunction and loss. However, treatments that stabilize neurons and prevent their destruction are still lacking. Here, we identify the histone methyltransferase G9a as a druggable… read more here.
Keywords: stress; neuronal vulnerability; g9a; anti ferroptotic ... See more keywords