Sensory neurons derived from diabetic rats exhibit deficits in functional glycolysis and ATP that are ameliorated by IGF-1
Sign Up to like & getrecommendations! Published in 2021 at "Molecular Metabolism"
DOI: 10.1016/j.molmet.2021.101191
Abstract: Objective The distal dying-back of the longest nerve fibres is a hallmark of diabetic neuropathy, and impaired provision of energy in the form of adenosine triphosphate (ATP) may contribute to this neurodegenerative process. We hypothesised… read more here.
Keywords: neurons derived; glycolysis; atp; drg neurons ... See more keywords
Presynaptic Dysfunction in Neurons Derived from Tay–Sachs iPSCs
Sign Up to like & getrecommendations! Published in 2019 at "Neuroscience"
DOI: 10.1016/j.neuroscience.2019.06.026
Abstract: Tay-Sachs disease (TSD) is a GM2 gangliosidosis lysosomal storage disease caused by a loss of lysosomal hexosaminidase-A (HEXA) activity and characterized by progressive neurodegeneration due to the massive accumulation of GM2 ganglioside in the brain.… read more here.
Keywords: neurons derived; tay sachs; ipscs; tsd ipscs ... See more keywords
Neurons derived from patients with bipolar disorder divide into intrinsically different sub-populations of neurons, predicting the patients’ responsiveness to lithium
Sign Up to like & getrecommendations! Published in 2018 at "Molecular Psychiatry"
DOI: 10.1038/mp.2016.260
Abstract: Bipolar disorder (BD) is a progressive psychiatric disorder with more than 3% prevalence worldwide. Affected individuals experience recurrent episodes of depression and mania, disrupting normal life and increasing the risk of suicide greatly. The complexity… read more here.
Keywords: sub populations; neurons derived; disorder; populations neurons ... See more keywords
Increased Ca2+ signaling in NRXN1α+/− neurons derived from ASD induced pluripotent stem cells
Sign Up to like & getrecommendations! Published in 2019 at "Molecular Autism"
DOI: 10.1186/s13229-019-0303-3
Abstract: BackgroundAutism spectrum disorder (ASD) is a neurodevelopmental disorder with a high co-morbidity of epilepsy and associated with hundreds of rare risk factors. NRXN1 deletion is among the commonest rare genetic factors shared by ASD, schizophrenia,… read more here.
Keywords: neurons derived; ca2 transients; increased ca2; derived asd ... See more keywords
Clozapine Reverses Dysfunction of Glutamatergic Neurons Derived From Clozapine-Responsive Schizophrenia Patients
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cellular Neuroscience"
DOI: 10.3389/fncel.2022.830757
Abstract: The cellular pathology of schizophrenia and the potential of antipsychotics to target underlying neuronal dysfunctions are still largely unknown. We employed glutamatergic neurons derived from induced pluripotent stem cells (iPSC) obtained from schizophrenia patients with… read more here.
Keywords: schizophrenia patients; glutamatergic neurons; schizophrenia; neurons derived ... See more keywords