Activation of G-protein-coupled receptor 30 protects neurons against excitotoxicity through inhibiting excessive autophagy induced by glutamate.
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DOI: 10.1021/acschemneuro.9b00287
Abstract: Autophagy is a protecting intracellular pathway to transmit unnecessary or dysfunctional components to the lysosome for degeneration. Autophagic imbalance is connected with neurodegeneration. Neurodegenerative diseases including Parkinson's disease, Alzheimer's disease, and Huntington's disease are closely… read more here.
Keywords: neurons excitotoxicity; protects neurons; autophagy; excessive autophagy ... See more keywords