Neu1 Is Released From Activated Microglia, Stimulating Microglial Phagocytosis and Sensitizing Neurons to Glutamate
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cellular Neuroscience"
DOI: 10.3389/fncel.2022.917884
Abstract: Neuraminidase 1 (Neu1) hydrolyses terminal sialic acid residues from glycoproteins and glycolipids, and is normally located in lysosomes, but can be released onto the surface of activated myeloid cells and microglia. We report that endotoxin/lipopolysaccharide-activated… read more here.
Keywords: neuronal death; phagocytosis; microglial phagocytosis; activated microglia ... See more keywords
Astrocytes enhance the tolerance of rat cortical neurons to glutamate excitotoxicity
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DOI: 10.3892/mmr.2018.9799
Abstract: Glutamate excitotoxicity is responsible for neuronal death in acute neurological disorders, including stroke, trauma and neurodegenerative diseases. Astrocytes are the main cells for the removal of glutamate in the synaptic cleft and may affect the… read more here.
Keywords: rat cortical; neurons glutamate; absence astrocytes; cortical neurons ... See more keywords