Metabotropic glutamate receptor subtype 7 in the dorsal striatum oppositely modulates pain in sham and neuropathic rats
Sign Up to like & getrecommendations! Published in 2018 at "Neuropharmacology"
DOI: 10.1016/j.neuropharm.2018.03.003
Abstract: &NA; The study investigated the role of the metabotropic glutamate receptor subtype 7 (mGluR7) in pain signalling in the dorsal striatum of sham and neuropathic rats. Supraspinal circuitries involved in the dorsal striatum control of… read more here.
Keywords: neuropathic rats; dorsal striatum; activity; pain ... See more keywords
Selective deficiencies in descending inhibitory modulation in neuropathic rats: implications for enhancing noradrenergic tone
Sign Up to like & getrecommendations! Published in 2018 at "Pain"
DOI: 10.1097/j.pain.0000000000001300
Abstract: Abstract Pontine noradrenergic neurones form part of a descending inhibitory system that influences spinal nociceptive processing. Weak or absent descending inhibition is a common feature of chronic pain patients. We examined the extent to which… read more here.
Keywords: spontaneous firing; control; inhibitory control; neuropathic rats ... See more keywords
Anxiolytic effects of hippocampal neurosteroids in normal and neuropathic rats with spared nerve injury
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Neurochemistry"
DOI: 10.1111/jnc.13965
Abstract: Neurosteroids are synthesized in the nervous system from cholesterol or steroidal precursors imported from peripheral sources. These compounds are important allosteric modulators of GABAA receptors, which play a vital role in modulating hippocampal functions. Chronic… read more here.
Keywords: spared nerve; anxiolytic effects; hippocampal neurosteroids; neuropathic rats ... See more keywords