Methylation of the AIM2 gene: An epigenetic mediator of PTSD-related inflammation and neuropathology plasma biomarkers.
Sign Up to like & getrecommendations! Published in 2022 at "Depression and anxiety"
DOI: 10.1002/da.23247
Abstract: BACKGROUND Posttraumatic stress disorder (PTSD) is associated with inflammation and various forms of chronic disease. The Absent in Melanoma 2 (AIM2) gene has been implicated in mechanisms of inflammation and anxiety, and methylation at a… read more here.
Keywords: inflammation neuropathology; neuropathology; methylation; ptsd ... See more keywords
Transcriptional Signatures of Tau and Amyloid Neuropathology
Sign Up to like & getrecommendations! Published in 2020 at "Cell Reports"
DOI: 10.1016/j.celrep.2020.01.063
Abstract: Summary Alzheimer’s disease (AD) is associated with the intracellular aggregation of hyperphosphorylated tau and the accumulation of β-amyloid in the neocortex. We use transgenic mice harboring human tau (rTg4510) and amyloid precursor protein (J20) mutations… read more here.
Keywords: transcriptional signatures; signatures tau; neuropathology; pathology ... See more keywords
First description of enhanced expression of transforming growth factor-alpha (TGF-α) and glia maturation factor-beta (GMF-β) correlate with severity of neuropathology in border disease virus-infected small ruminants.
Sign Up to like & getrecommendations! Published in 2019 at "Microbial pathogenesis"
DOI: 10.1016/j.micpath.2019.01.015
Abstract: Border disease (BD) is caused by Pestivirus and characterized by severe neuropathology, and histopathologically observed severe hypomyelination. We have previously shown that small ruminants infected with border disease virus (BDV) play an important role for… read more here.
Keywords: border disease; neuropathology; expression; gmf ... See more keywords
Neuropathology of Chiari Malformation II with Chromosome X Alterations: An Autopsy Study in a 17-Month-Old and Review of Literature.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of neuropathology and experimental neurology"
DOI: 10.1093/jnen/nlab137
Abstract: To the Editor: Type II Chiari malformation (CMII), also known as “Arnold-Chiari malformation,” is a rare hindbrain anomality characterized by a small posterior fossa with downward descent of cerebellum, brainstem, and fourth ventricle (1). Although… read more here.
Keywords: autopsy study; month old; malformation; neuropathology ... See more keywords
Chronic Traumatic Encephalopathy in a Routine Neuropathology Service in Australia.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of neuropathology and experimental neurology"
DOI: 10.1093/jnen/nlac071
Abstract: Chronic traumatic encephalopathy (CTE) is a neuropathological diagnosis defined by a unique pattern of hyperphosphorylated tau (p-tau) accumulation that begins in neocortical regions of the brain. It is associated with a range of neuropsychological symptoms,… read more here.
Keywords: neuropathology; brain; chronic traumatic; traumatic encephalopathy ... See more keywords
Neuropathology and Ophthalmological Pathology of Fatal Central Nervous System Injuries in Young Children: Forensic Neuropathology of Deaths of Children Under Age 2, 2008-2016, in Central Missouri.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of neuropathology and experimental neurology"
DOI: 10.1093/jnen/nlac083
Abstract: Nonaccidental head injuries are significant causes of morbidity and mortality among young children. Despite broad agreement among medical experts, controversies remain over diagnostic criteria, including from autopsies, because of opinions expressed by a small group… read more here.
Keywords: young children; neuropathology; pathology; children age ... See more keywords
Neuropathology in Neonatal Mice After Experimental Coxsackievirus B2 Infection Using a Prototype Strain, Ohio-1.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of neuropathology and experimental neurology"
DOI: 10.1093/jnen/nlz124
Abstract: Coxsackievirus B (CVB) causes severe morbidity and mortality in neonates and is sometimes associated with severe brain damage resulting from acute severe viral encephalomyelitis. However, the neuropathology of CVB infection remains unclear. A prototype strain… read more here.
Keywords: neuropathology; infection; neonatal mice; prototype strain ... See more keywords
LINC-11. NEUROPATHOLOGY REVIEW OF LATIN AMERICAN CHILDHOOD AND ADOLESCENT BRAIN TUMOR PATIENTS: A MULTI-NATIONAL, MULTI-DISCIPLINARY PEDIATRIC NEURO-ONCOLOGY TELECONFERENCE EXPERIENCE
Sign Up to like & getrecommendations! Published in 2020 at "Neuro-Oncology"
DOI: 10.1093/neuonc/noaa222.446
Abstract: Abstract BACKGROUND Pediatric brain tumor classification has undergone significant evolution over the last decade requiring a high-level of expertise and diagnostic techniques. Such advances have created challenges for pathologists particularly in low-to-middle income countries (LMIC).… read more here.
Keywords: neuropathology; pediatric neuro; pathology; neuro oncology ... See more keywords
60. The Role of GABA in the Neurobiology of Schizophrenia: A Preclinical, Clinical, and Neuropathology Update.
Sign Up to like & getrecommendations! Published in 2017 at "Schizophrenia Bulletin"
DOI: 10.1093/schbul/sbx021.087
Abstract: Overall Abstract: Animal models of psychosis indicate a new focus on altered GABAergic neurotransmission as the source of subcortical dopamine dysfunction in schizophrenia. While neuroimaging research allows testing the relevance of these models in humans,… read more here.
Keywords: schizophrenia; neuropathology; gaba; role ... See more keywords
The Contribution of Neuropathology to Multiple Sclerosis Research.
Sign Up to like & getrecommendations! Published in 2022 at "European journal of neurology"
DOI: 10.1111/ene.15360
Abstract: BACKGROUND Neuropathology played a major role in deciphering disease mechanisms in multiple sclerosis. METHODS Retrospective review of neuropathological studies, published during the last two decades. RESULTS The importance of neuropathology is generally seen in its… read more here.
Keywords: neuropathology; sclerosis research; multiple sclerosis; disease ... See more keywords
Peripheral inflammation exacerbates α‐synuclein toxicity and neuropathology in Parkinson's models
Sign Up to like & getrecommendations! Published in 2020 at "Neuropathology and Applied Neurobiology"
DOI: 10.1111/nan.12644
Abstract: Parkinson’s disease and related disorders are devastating neurodegenerative pathologies. Since α‐synuclein was identified as a main component of Lewy bodies and neurites, efforts have been made to clarify the pathogenic mechanisms of α‐synuclein's detrimental effects.… read more here.
Keywords: inflammation exacerbates; neuropathology; parkinson; inflammation ... See more keywords