Targeting spinal neuropeptide Y1 receptor-expressing interneurons to alleviate chronic pain and itch
Sign Up to like & getrecommendations! Published in 2021 at "Progress in Neurobiology"
DOI: 10.1016/j.pneurobio.2020.101894
Abstract: An accelerating basic science literature is providing key insights into the mechanisms by which spinal neuropeptide Y (NPY) inhibits chronic pain. A key target of pain inhibition is the Gi-coupled neuropeptide Y1 receptor (Y1). Y1… read more here.
Keywords: neuropeptide receptor; pain itch; spinal neuropeptide; chronic pain ... See more keywords
Structure-Based Design of High-Affinity Fluorescent Probes for the Neuropeptide Y Y1 Receptor.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.1c02033
Abstract: The recent crystallization of the neuropeptide Y Y1 receptor (Y1R) in complex with the argininamide-type Y1R selective antagonist UR-MK299 (2) opened up a new approach toward structure-based design of nonpeptidic Y1R ligands. We designed novel… read more here.
Keywords: based design; neuropeptide receptor; fluorescent; y1r ... See more keywords
Diet-induced adaptive thermogenesis requires neuropeptide FF receptor-2 signalling
Sign Up to like & getrecommendations! Published in 2018 at "Nature Communications"
DOI: 10.1038/s41467-018-06462-0
Abstract: Excess caloric intake results in increased fat accumulation and an increase in energy expenditure via diet-induced adaptive thermogenesis; however, the underlying mechanisms controlling these processes are unclear. Here we identify the neuropeptide FF receptor-2 (NPFFR2)… read more here.
Keywords: thermogenesis; neuropeptide receptor; diet induced; induced adaptive ... See more keywords
Neuropeptide receptor genes GHSR and NMUR1 are candidate epigenetic biomarkers and predictors for surgically treated patients with oropharyngeal cancer
Sign Up to like & getrecommendations! Published in 2020 at "Scientific Reports"
DOI: 10.1038/s41598-020-57920-z
Abstract: Pathological staging and histological grading systems are useful, but imperfect, predictors of recurrence in head and neck squamous cell carcinoma (HNSCC). Aberrant promoter methylation is the main type of epigenetic modification that plays a role… read more here.
Keywords: methylation; neuropeptide receptor; methylation status; promoter methylation ... See more keywords
Spinal neuropeptide Y Y1 receptor-expressing neurons are a pharmacotherapeutic target for the alleviation of neuropathic pain
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2204515119
Abstract: Significance Neuropathic pain is a debilitating chronic pain condition that is poorly responsive to currently available analgesic drugs. A widespread clinical need remains for novel, safe, and efficacious nonopioid therapeutics for afflicted patients. Using a… read more here.
Keywords: neuropeptide receptor; receptor expressing; neuropathic pain; pain ... See more keywords
Association between neuropeptide Y receptor Y2 promoter variant rs6857715 and major depressive disorder
Sign Up to like & getrecommendations! Published in 2017 at "Psychiatric Genetics"
DOI: 10.1097/ypg.0000000000000149
Abstract: Stress increases the risk for major depressive disorder (MDD), overeating, and alcohol dependence (AD). The neuropeptide Y system is one of the best-known modulators of the stress response, and some of its effects are mediated… read more here.
Keywords: neuropeptide receptor; depressive disorder; rs6857715; variant rs6857715 ... See more keywords
Identification of a Novel Neuropeptide S Receptor Antagonist Scaffold Based on the SHA-68 Core
Sign Up to like & getrecommendations! Published in 2021 at "Pharmaceuticals"
DOI: 10.3390/ph14101024
Abstract: Activation of the neuropeptide S receptor (NPSR) system has been shown to produce anxiolytic-like actions, arousal, and enhance memory consolidation, whereas blockade of the NPSR has been shown to reduce relapse to substances of abuse… read more here.
Keywords: receptor antagonist; neuropeptide receptor; novel neuropeptide; identification novel ... See more keywords