Synthesis and neuroprotective activity of novel 1,2,4-triazine derivatives with ethyl acetate moiety against H2O2 and Aβ-induced neurotoxicity
Sign Up to like & getrecommendations! Published in 2017 at "Medicinal Chemistry Research"
DOI: 10.1007/s00044-017-2003-x
Abstract: A series of 5,6-diaryl-1,2,4-triazine-3-thioacetate derivatives 3a–f, 8a–d and their regioisomer 8e were synthesized. Neuroprotective activity of compounds was assessed against H2O2 and β-amyloid-induced toxicity in PC12 and SH-SY5Y cells respectively. Surprisingly, ethyl 2-(5-(4-chlorophenyl)-6-(4-methoxyphenyl)-3-thioxo-1,2,4-triazin-2(3H)-yl)acetate (8e) was… read more here.
Keywords: activity novel; synthesis neuroprotective; h2o2 induced; neuroprotective activity ... See more keywords
Cilostazol Mediated Nurr1 and Autophagy Enhancement: Neuroprotective Activity in Rat Rotenone PD Model
Sign Up to like & getrecommendations! Published in 2018 at "Molecular Neurobiology"
DOI: 10.1007/s12035-018-0923-1
Abstract: AbstractNuclear receptor related 1 (Nurr1) orphan receptor has emerged as a promising contender in ameliorating Parkinson’s disease; thus, finding a suitable activator of Nurr1 receptor is an attracting target for treating PD. Cilostazol, a phosphodiesterase-3… read more here.
Keywords: model; rat rotenone; cilostazol; neuroprotective activity ... See more keywords
Isolation of Fluorescent Benzoxazines with Neuroprotective Activity from the Olive Weevil Pimelocerus perforatus.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of natural products"
DOI: 10.1021/acs.jnatprod.2c00670
Abstract: The weevil Pimelocerus perforatus poses a serious pest problem for olive cultivation in Japan. Two new racemic fluorescent benzoxazines, designated as pimeforazine A ((±)-1) and pimeforazine B ((±)-2), were successfully isolated from P. perforatus. Their… read more here.
Keywords: weevil pimelocerus; pimelocerus perforatus; neuroprotective activity; perforatus ... See more keywords
2,6-Disubstituted Piperidine Alkaloids with Neuroprotective Activity from Hippobroma longiflora
Sign Up to like & getrecommendations! Published in 2022 at "Planta Medica"
DOI: 10.1055/a-1903-2663
Abstract: Abstract Three new alkaloids, hipporidine A ( 1 ), hipporidine B ( 2 ), and (−)-lobeline N -oxide ( 3 ), were discovered from the whole plant of Hippobroma longiflora together with five known compounds… read more here.
Keywords: disubstituted piperidine; neuroprotective activity; hippobroma longiflora; alkaloids neuroprotective ... See more keywords
New benzofuran neolignans with neuroprotective activity from Phyllanthodendron breynioides.
Sign Up to like & getrecommendations! Published in 2022 at "Natural product research"
DOI: 10.1080/14786419.2022.2153454
Abstract: A pair of undescribed dihydrobenzofuran neolignan enantiomers, (+/-)-phybrenan A (1a/1b), two new benzofuran neolignans, phybrenan B and C (2 and 3), along with four known neolignans (4 - 7) were obtained from the plants of Phyllanthodendron breynioides… read more here.
Keywords: benzofuran neolignans; new benzofuran; neuroprotective activity; neolignans neuroprotective ... See more keywords
Involvement of adenosine triphosphate-sensitive potassium channels in the neuroprotective activity of hydrogen sulfide in the 6-hydroxydopamine-induced animal model of Parkinson’s disease
Sign Up to like & getrecommendations! Published in 2018 at "Behavioural Pharmacology"
DOI: 10.1097/fbp.0000000000000358
Abstract: Studies have shown that hydrogen sulfide (H2S) exerts a neuroprotective effect and may have a therapeutic value for treating neurodegenerative diseases including Parkinson's disease. However, little is known about the mechanisms underlying the neuroprotective activity… read more here.
Keywords: sensitive potassium; animal model; parkinson; parkinson disease ... See more keywords
Tetrahydrocannabinolic acid is a potent PPARγ agonist with neuroprotective activity
Sign Up to like & getrecommendations! Published in 2017 at "British Journal of Pharmacology"
DOI: 10.1111/bph.14019
Abstract: Phytocannabinoids are produced in Cannabis sativa L. in acidic form and are decarboxylated upon heating, processing and storage. While the biological effects of decarboxylated cannabinoids such as Δ9‐tetrahydrocannabinol have been extensively investigated, the bioactivity of… read more here.
Keywords: acid potent; agonist neuroprotective; potent ppar; ppar agonist ... See more keywords
Niazimicin: A thiocarbamate glycoside from Moringa oleifera Lam. seeds with a novel neuroprotective activity.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of food biochemistry"
DOI: 10.1111/jfbc.13992
Abstract: Moringa oleifera (MO) known as the miracle tree is a famous nutritional source in many countries. In this study, the neuroprotective activity of MO seeds was investigated. Fractions of the 70% ethanol seed extract of… read more here.
Keywords: niazimicin thiocarbamate; neuroprotective activity; moringa; moringa oleifera ... See more keywords
Antioxidant and Neuroprotective Activity of Extra Virgin Olive Oil Extracts Obtained from Quercetano Cultivar Trees Grown in Different Areas of the Tuscany Region (Italy)
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DOI: 10.3390/antiox10030421
Abstract: Neurodegenerative diseases are driven by several mechanisms such as inflammation, abnormal protein aggregation, excitotoxicity, mitochondrial dysfunction and oxidative stress. So far, no therapeutic strategies are available for neurodegenerative diseases and in recent years the research… read more here.
Keywords: extra virgin; extracts obtained; virgin olive; antioxidant neuroprotective ... See more keywords
Mechanisms Underlying Neurodegenerative Disorders and Potential Neuroprotective Activity of Agrifood By-Products
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DOI: 10.3390/antiox12010094
Abstract: Neurodegenerative diseases, characterized by progressive loss in selected areas of the nervous system, are becoming increasingly prevalent worldwide due to an aging population. Despite their diverse clinical manifestations, neurodegenerative diseases are multifactorial disorders with standard… read more here.
Keywords: neuroprotective activity; agrifood products; potential neuroprotective; agrifood ... See more keywords
Preparation and Neuroprotective Activity of Glucuronomannan Oligosaccharides in an MPTP-Induced Parkinson’s Model
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DOI: 10.3390/md18090438
Abstract: Parkinson’s disease (PD), characterized by dopaminergic neuron degeneration in the substantia nigra and dopamine depletion in the striatum, affects up to 1% of the global population over 50 years of age. Our previous study found… read more here.
Keywords: glucuronomannan oligosaccharides; preparation neuroprotective; parkinson; activity glucuronomannan ... See more keywords