First dual AK/GSK-3β inhibitors endowed with antioxidant properties as multifunctional, potential neuroprotective agents.
Sign Up to like & getrecommendations! Published in 2017 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2017.06.017
Abstract: The manuscript deals with the design, synthesis and biological evaluation of novel benzoxazinone-based and indole-based compounds as multifunctional neuroprotective agents. These compounds inhibit human adenosine kinase (hAK) and human glycogen synthase kinase 3 beta (hGSK-3β)… read more here.
Keywords: first dual; endowed antioxidant; dual gsk; gsk inhibitors ... See more keywords
Design, synthesis and biological evaluation of LX2343 derivatives as neuroprotective agents for the treatment of Alzheimer's disease.
Sign Up to like & getrecommendations! Published in 2018 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2017.12.080
Abstract: A series of LX2343 derivatives were designed, synthesized and evaluated as neuroprotective agents for Alzheimer's disease (AD) in vitro. Most of the compounds displayed potent neuroprotective activities. Especially for compound A6, exhibited a remarkable EC50 value… read more here.
Keywords: lx2343 derivatives; neuroprotective agents; alzheimer disease; disease ... See more keywords
Recent advances in the development of neuroprotective agents and therapeutic targets in the treatment of cerebral ischemia.
Sign Up to like & getrecommendations! Published in 2019 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2018.11.014
Abstract: Stroke is a central nervous system disease that seriously affects people's quality of life and has the second highest rate of morbidity and mortality in the world. At present, clinical treatment strategies for acute ischemic… read more here.
Keywords: advances development; treatment; therapeutic targets; recent advances ... See more keywords
Investigations on 16-Arylideno Steroids as a New Class of Neuroprotective Agents for the Treatment of Alzheimer's and Parkinson's Diseases.
Sign Up to like & getrecommendations! Published in 2017 at "ACS chemical neuroscience"
DOI: 10.1021/acschemneuro.6b00313
Abstract: Neuroinflammatory mechanisms mediated by activated glial and cytokines (TNF-α, IL-1β) might contribute to neuronal degeneration leading to Alzheimer's (AD) and Parkinson's disease (PD). Lipopolysaccharide (LPS) is an inflammogen derived from the cell wall of Gram-negative… read more here.
Keywords: steroidal derivatives; treatment; investigations arylideno; alzheimer parkinson ... See more keywords
Molecular Mechanisms of Neurotoxicity Induced by Polymyxins and Chemoprevention.
Sign Up to like & getrecommendations! Published in 2019 at "ACS chemical neuroscience"
DOI: 10.1021/acschemneuro.8b00300
Abstract: Neurotoxicity is one major unwanted side-effects associated with polymyxin (i.e., colistin and polymyxin B) therapy. Clinically, colistin neurotoxicity is characterized by neurological symptoms including dizziness, visual disturbances, vertigo, confusion, hallucinations, seizures, ataxia, and facial and… read more here.
Keywords: polymyxin induced; induced neurotoxicity; neurotoxicity; polymyxin ... See more keywords
Neuroprotective agents in the management of glaucoma
Sign Up to like & getrecommendations! Published in 2018 at "Eye"
DOI: 10.1038/s41433-018-0050-2
Abstract: Glaucoma is an optic neuropathy, specifically a neurodegenerative disease characterized by loss of retinal ganglion cells (RGCs) and their axons. The pathogenesis of RGC loss in glaucoma remains incompletely understood and a broad range of… read more here.
Keywords: glaucoma; management glaucoma; agents management; neuroprotective agents ... See more keywords
The use of neuroprotective agents in treating geographic atrophy.
Sign Up to like & getrecommendations! Published in 2021 at "Ophthalmic research"
DOI: 10.1159/000517794
Abstract: Disclaimer: Accepted, unedited article not yet assigned to an issue. The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publisher and the… read more here.
Keywords: agents treating; treating geographic; use neuroprotective; geographic atrophy ... See more keywords
Sulfur-containing secondary metabolites as neuroprotective agents.
Sign Up to like & getrecommendations! Published in 2018 at "Current medicinal chemistry"
DOI: 10.2174/0929867325666180912105036
Abstract: Sulfur containing secondary metabolites are a relatively small group of substances of plant origin. The present review is focused on their neuroprotective properties. The results obtained in a series of in vitro and in vivo… read more here.
Keywords: sulfur containing; containing secondary; metabolites neuroprotective; secondary metabolites ... See more keywords
Terazosin Analogs Targeting Pgk1 as Neuroprotective Agents: Design, Synthesis, and Evaluation
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Chemistry"
DOI: 10.3389/fchem.2022.906974
Abstract: Nitrogen-containing heterocyclic compounds have shown promising therapeutic effects in a variety of inflammatory and neurodegenerative diseases. Recently, terazosin (TZ), a heterocyclic compound with a quinazoline core, was found to combine with phosphoglycerol kinase 1 (Pgk1)… read more here.
Keywords: targeting pgk1; terazosin analogs; neuroprotective agents; analogs targeting ... See more keywords
Progresses and Prospects of Neuroprotective Agents-Loaded Nanoparticles and Biomimetic Material in Ischemic Stroke
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cellular Neuroscience"
DOI: 10.3389/fncel.2022.868323
Abstract: Ischemic stroke remains the leading cause of death and disability, while the main mechanisms of dominant neurological damage in stroke contain excitotoxicity, oxidative stress, and inflammation. The clinical application of many neuroprotective agents is limited… read more here.
Keywords: prospects neuroprotective; neuroprotective agents; agents loaded; progresses prospects ... See more keywords