The neuroprotective effect and possible therapeutic application of xenon in neurological diseases.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of neuroscience research"
DOI: 10.1002/jnr.24958
Abstract: Xenon is an inert gas with stable chemical properties which is used as an anesthetic. Recent in vitro and in vivo findings indicate that xenon also elicits an excellent neuroprotective effect in subanesthetic concentrations. The… read more here.
Keywords: neuroprotective effect; xenon; neurological diseases; possible therapeutic ... See more keywords
The potential off-target neuroprotective effect of sister gliflozins suggest their repurposing despite not crossing the blood brain barrier: From bioanalytical assay in rats into theory genesis.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of separation science"
DOI: 10.1002/jssc.202200921
Abstract: Gliflozins are successfully marketed antidiabetic agents with a reported neuroprotective effect, this study tests their blood-brain barrier crossing ability. Henceforward, a computational hypothesis interpreting their effects was reasonable after failure to cross into the brain.… read more here.
Keywords: blood brain; neuroprotective effect; brain barrier; brain ... See more keywords
Neuroprotective Effect of σ1-Receptors on the Cell Model of Huntington’s Disease
Sign Up to like & getrecommendations! Published in 2017 at "Bulletin of Experimental Biology and Medicine"
DOI: 10.1007/s10517-017-3968-7
Abstract: Huntington’s disease is a hereditary neurodegenerative disease that primarily affects striatal neurons. Recent studies demonstrated abnormalities in calcium regulation in striatal neurons in Huntington’s disease, which leads to elimination of synaptic connections between cortical and… read more here.
Keywords: neuroprotective effect; receptors cell; huntington disease; striatal neurons ... See more keywords
Knockdown of microRNA-17-5p Enhances the Neuroprotective Effect of Act A/Smads Signal Loop After Ischemic Injury
Sign Up to like & getrecommendations! Published in 2019 at "Neurochemical Research"
DOI: 10.1007/s11064-019-02815-3
Abstract: Cerebral ischemic injury is a leading cause of human mortality and disability, seriously threatening human health in the world. Activin A (Act A), as a well-known neuroprotective factor, could alleviate ischemic brain injury mainly through… read more here.
Keywords: neuroprotective effect; act; signal loop; act smads ... See more keywords
Evaluation of the Neuroprotective Effect of Sirt3 in Experimental Stroke
Sign Up to like & getrecommendations! Published in 2017 at "Translational Stroke Research"
DOI: 10.1007/s12975-017-0603-x
Abstract: Sirtuins (Sirt) are a family of NAD+ dependent histone deacetylase (HDAC) proteins implicated in aging, cell cycle regulation, and metabolism. These proteins are involved in the epigenetic modification of neuromodulatory proteins after strokevia acetylation/deacetylation. The… read more here.
Keywords: neuroprotective effect; effect sirt3; sirt3 mice; evaluation neuroprotective ... See more keywords
Midazolam contributes to neuroprotection against hypoxia/reoxygenation-induced brain injury in neonatal rats via regulation of EAAT2
Sign Up to like & getrecommendations! Published in 2020 at "Brain Research Bulletin"
DOI: 10.1016/j.brainresbull.2020.04.016
Abstract: Excitotoxicity is one of the main mechanisms related to hypoxia/reoxygenation (H/R) injury. Excitatory amino acid transporter (EAAT)2 mainly distributes on astrocytes and plays an important role on glutamate reuptake and glutamate homeostasis. Midazolam has a… read more here.
Keywords: neuroprotective effect; hypoxia reoxygenation; midazolam; brain ... See more keywords
Role of interleukin‐10 in the neuroprotective effect of the Angiotensin Type 2 Receptor agonist, compound 21, after ischemia/reperfusion injury
Sign Up to like & getrecommendations! Published in 2017 at "European Journal of Pharmacology"
DOI: 10.1016/j.ejphar.2017.02.016
Abstract: Introduction We and others have shown that the angiotensin type 2 (AT2) receptor agonist, compound 21 (C21), provides neuroprotection and enhances recovery in rodent stroke models yet the mechanism involved is not known. Moreover, C21… read more here.
Keywords: neuroprotective effect; agonist compound; receptor agonist; c21 ... See more keywords
Structural elucidation of a polysaccharide from Lonicera japonica flowers, and its neuroprotective effect on cerebral ischemia-reperfusion injury in rat.
Sign Up to like & getrecommendations! Published in 2017 at "International journal of biological macromolecules"
DOI: 10.1016/j.ijbiomac.2017.02.096
Abstract: A water-soluble polysaccharide, LJPB2, was purified from Lonicera japonica flowers. The present study was aimed to illustrate its structural features and its neuroprotective effect via anti-oxidant activity on focal ischemia/reperfusion (I/R) injury in rat brain.… read more here.
Keywords: ischemia reperfusion; neuroprotective effect; reperfusion injury;
Egg yolk phosphatidylcholine: Extraction, purification and its potential neuroprotective effect on PC12 cells
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Functional Foods"
DOI: 10.1016/j.jff.2019.03.037
Abstract: Abstract Phosphatidylcholine (PC), a main phospholipid component in egg yolk, provides nourishment and protection for the body. In this study, an attempt has been made to explore the neuroprotective effect of PC that extracted and… read more here.
Keywords: egg; egg yolk; neuroprotective effect; pc12 ... See more keywords
ERK activation by zeranol has neuroprotective effect in cerebral ischemia reperfusion.
Sign Up to like & getrecommendations! Published in 2019 at "Life sciences"
DOI: 10.1016/j.lfs.2019.04.035
Abstract: AIMS Incidence of stroke increases in postmenopausal women with dangerous consequences. In this study we used zeranol to protect ovariectomized (OVX) rats against cerebral I/R damage and our target is to identify the mechanism of… read more here.
Keywords: neuroprotective effect; group; reperfusion; zeranol ... See more keywords
Neuroprotective effect of damaurone D in a C. elegans model of Parkinson’s disease
Sign Up to like & getrecommendations! Published in 2021 at "Neuroscience Letters"
DOI: 10.1016/j.neulet.2021.135623
Abstract: In this study, we evaluated the protective effects of damaurone D (DaD), a dihydropyranoaurone compound, on dopaminergic (DA) neurodegeneration in Caenorhabditis elegans. The results showed that DaD treatment could successfully increase the survival rate of… read more here.
Keywords: neuroprotective effect; induced neurodegeneration; dad; parkinson disease ... See more keywords