Griseocazines: Neuroprotective Multiprenylated Cyclodipeptides Identified through Targeted Genome Mining.
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DOI: 10.1021/acs.orglett.2c00745
Abstract: Prenylation can impart pharmacological advantages to bioactive compounds. Global genome mining for prenylated cyclodipeptides identified a gczABC BGC from Streptomyces griseocarneus 132 containing a cyclodipeptide synthase and two prenyltransferase genes. Subsequent heterologous expression allowed isolation… read more here.
Keywords: neuroprotective multiprenylated; griseocazines neuroprotective; cyclodipeptides identified; genome mining ... See more keywords