L-Tryptophan-kynurenine pathway enzymes are therapeutic target for neuropsychiatric diseases: Focus on cell type differences
Sign Up to like & getrecommendations! Published in 2017 at "Neuropharmacology"
DOI: 10.1016/j.neuropharm.2016.01.011
Abstract: ABSTRACT The kynurenine pathway (KP) is the major route for tryptophan (TRP) metabolism in most mammalian tissues. The KP metabolizes TRP into a number of neuroactive metabolites, such as kynurenine (KYN), kynurenic acid (KYNA), 3‐hydroxykynurenine… read more here.
Keywords: neuropsychiatric diseases; expression; kynurenine pathway; cell ... See more keywords
Oleanolic acid and ursolic acid: therapeutic potential in neurodegenerative diseases, neuropsychiatric diseases and other brain disorders
Sign Up to like & getrecommendations! Published in 2022 at "Nutritional Neuroscience"
DOI: 10.1080/1028415x.2022.2051957
Abstract: ABSTRACT Brain disorders such as neurodegenerative diseases and neuropsychiatric diseases have become serious threatens to human health and quality of life. Oleanolic acid (OA) and ursolic acid (UA) are pentacyclic triterpenoid isomers widely distributed in… read more here.
Keywords: neuropsychiatric diseases; brain; diseases neuropsychiatric; neurodegenerative diseases ... See more keywords
Long-term sustained release Poly(lactic-co-glycolic acid) microspheres of asenapine maleate with improved bioavailability for chronic neuropsychiatric diseases
Sign Up to like & getrecommendations! Published in 2020 at "Drug Delivery"
DOI: 10.1080/10717544.2020.1815896
Abstract: Abstract Schizophrenia and bipolar disorder are severe chronic neuropsychiatric diseases, affecting hundreds of millions of people worldwide. Asenapine maleate (ASM) has been demonstrated as a safe and effective therapeutic agent under twice-daily administration. However, lower… read more here.
Keywords: chronic neuropsychiatric; neuropsychiatric diseases; asm; bioavailability ... See more keywords
Static and Dynamic Functional Connectivity Alterations in Alzheimer's Disease and Neuropsychiatric Diseases.
Sign Up to like & getrecommendations! Published in 2022 at "Brain connectivity"
DOI: 10.1089/brain.2022.0044
Abstract: To date, numerous studies have documented various alterations in resting brain activity in Alzheimer's disease (AD) and other neuropsychiatric diseases. In particular, disease-related alterations of functional connectivity (FC) in the resting state networks (RSN) have… read more here.
Keywords: connectivity; neuropsychiatric diseases; alzheimer disease; disease neuropsychiatric ... See more keywords
High throughput CRISPRi and CRISPRa technologies in 3D genome regulation for neuropsychiatric diseases.
Sign Up to like & getrecommendations! Published in 2022 at "Human molecular genetics"
DOI: 10.1093/hmg/ddac193
Abstract: Advances in genomics have led to the identification of many risk loci with hundreds of genes and thousands of DNA variants associated with neuropsychiatric disorders. A significant barrier to understanding the genetic underpinnings of complex… read more here.
Keywords: neuropsychiatric diseases; crispra; high throughput; crispri crispra ... See more keywords
F200. ELUCIDATING THE ROLE OF CILIA IN NEUROPSYCHIATRIC DISEASES THROUGH INTERACTOME ANALYSIS
Sign Up to like & getrecommendations! Published in 2018 at "Schizophrenia Bulletin"
DOI: 10.1093/schbul/sby017.731
Abstract: Abstract Background Cilia are microtubule-based organelles present on the surface of many eukaryotic cell types critical for tissue homeostasis and proper organ development. Ciliary dysfunction underlies a growing list of human diseases and disorders collectively… read more here.
Keywords: ppis; schizophrenia; neuropsychiatric diseases; disorder ... See more keywords
Progress on the roles of MEF2C in neuropsychiatric diseases
Sign Up to like & getrecommendations! Published in 2022 at "Molecular Brain"
DOI: 10.1186/s13041-021-00892-6
Abstract: Myocyte Enhancer Factor 2 C (MEF2C), one of the transcription factors of the MADS-BOX family, is involved in embryonic brain development, neuronal formation and differentiation, as well as in the growth and pruning of axons… read more here.
Keywords: roles mef2c; progress roles; mef2c neuropsychiatric; neuropsychiatric diseases ... See more keywords
The Role of Gut Microbiota in Neuropsychiatric Diseases – Creation of An Atlas-Based on Quantified Evidence
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cellular and Infection Microbiology"
DOI: 10.3389/fcimb.2022.831666
Abstract: There is a growing body of evidence highlighting the significant role of gut microbiota in various pathologies. We performed a systematic review to review the different microbiota involved in neuropsychiatric diseases. 50 studies (23 studies… read more here.
Keywords: gut; neuropsychiatric diseases; gut microbiota; evidence ... See more keywords
Modulating brain integrative actions as a new perspective on pharmacological approaches to neuropsychiatric diseases
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Endocrinology"
DOI: 10.3389/fendo.2022.1038874
Abstract: A critical aspect of drug development in the therapy of neuropsychiatric diseases is the “Target Problem”, that is, the selection of a proper target after not simply the etiopathological classification but rather the detection of… read more here.
Keywords: modulating brain; network; neuropsychiatric diseases; brain ... See more keywords