Rates of Neuropsychiatric Disorders and Gestational Age at Birth in a Danish Population
Sign Up to like & getrecommendations! Published in 2021 at "JAMA Network Open"
DOI: 10.1001/jamanetworkopen.2021.14913
Abstract: Key Points Question Are there associations between gestational age, analyzed in 6 subgroups covering the full range of gestational duration, and the rate of neuropsychiatric diagnoses? Findings In this Danish, nationwide, registry-based cohort study, shortened… read more here.
Keywords: age birth; rates neuropsychiatric; gestational age; disorders gestational ... See more keywords
Therapeutic plasma exchange in adolescent and adult patients with autoimmune neuropsychiatric disorders associated with streptococcal infections
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Clinical Apheresis"
DOI: 10.1002/jca.22023
Abstract: Pediatric autoimmune neuropsychiatric disorders associated with streptococcal (PANDAS) infections and pediatric acute‐onset neuropsychiatric syndrome (PANS) are typically diagnosed in childhood. Therapeutic plasma exchange (TPE) has been recommended to remove relevant antibodies and treat symptomatic presentations… read more here.
Keywords: associated streptococcal; disorders associated; therapeutic plasma; plasma exchange ... See more keywords
Unraveling the genetic architecture of copy number variants associated with schizophrenia and other neuropsychiatric disorders
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Neuroscience Research"
DOI: 10.1002/jnr.23970
Abstract: Recent studies show that the complex genetic architecture of schizophrenia (SZ) is driven in part by polygenic components, or the cumulative effect of variants of small effect in many genes, as well as rare single‐locus… read more here.
Keywords: genetic architecture; number variants; copy number; neuropsychiatric disorders ... See more keywords
POGZ de novo missense variants in neuropsychiatric disorders
Sign Up to like & getrecommendations! Published in 2019 at "Molecular Genetics & Genomic Medicine"
DOI: 10.1002/mgg3.900
Abstract: De novo likely gene‐disrupting variants of POGZ cause autism spectrum disorder (ASD) and intellectual disability. However, de novo missense variants of this gene were not well explored in neuropsychiatric disorders. read more here.
Keywords: missense variants; novo missense; variants neuropsychiatric; pogz novo ... See more keywords
Exosomal MicroRNAs as Potential Biomarkers in Neuropsychiatric Disorders.
Sign Up to like & getrecommendations! Published in 2018 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-7601-0_6
Abstract: This chapter will discuss the potential use of microRNAs, particularly those located in peripherally-isolated exosomes, as biomarkers in neuropsychiatric disorders. These extracellular vesicles are released as a form of cell-to-cell communication and may mediate the… read more here.
Keywords: exosomal micrornas; biomarkers neuropsychiatric; potential biomarkers; micrornas potential ... See more keywords
Modeling Psychiatric Diseases with Induced Pluripotent Stem Cells.
Sign Up to like & getrecommendations! Published in 2019 at "Advances in experimental medicine and biology"
DOI: 10.1007/978-981-32-9721-0_15
Abstract: Neuropsychiatric disorders are a heterogeneous group of disorders that are challenging to model and treat, due to their underlying complex genetic architecture and clinical variability. Presently, increasingly more studies are making use of induced pluripotent… read more here.
Keywords: derived neurons; biology; pluripotent stem; induced pluripotent ... See more keywords
Role of Astrocytes in Major Neuropsychiatric Disorders.
Sign Up to like & getrecommendations! Published in 2021 at "Neurochemical research"
DOI: 10.1007/s11064-020-03212-x
Abstract: Astrocytes are the primary homeostatic cells of the central nervous system, essential for normal neuronal development and function, metabolism and response to injury and inflammation. Here, we review postmortem studies examining changes in astrocytes in… read more here.
Keywords: role astrocytes; major neuropsychiatric; neuropsychiatric disorders; astrocytes major ... See more keywords
Emerging evidence for the role of pituitary adenylate cyclase-activating peptide in neuropsychiatric disorders.
Sign Up to like & getrecommendations! Published in 2019 at "Progress in molecular biology and translational science"
DOI: 10.1016/bs.pmbts.2019.06.009
Abstract: Stress activates many brain nuclei and causes acute changes in several physiological and behavioral responses to restore homeostasis in affected organisms. While this response is protective, chronic stress exposure causes the sustained activation of these… read more here.
Keywords: cyclase activating; neuropsychiatric disorders; emerging evidence; stress ... See more keywords
Characteristics and outcomes of COVID-19 inpatients who underwent psychiatric consultations
Sign Up to like & getrecommendations! Published in 2021 at "Asian Journal of Psychiatry"
DOI: 10.1016/j.ajp.2021.102563
Abstract: Patients hospitalized with COVID-19 are at risk of developing many neuropsychiatric disorders, due to the effects of the disease on the brain and the psychosocial pressures of having the disease. The aim of the present… read more here.
Keywords: characteristics outcomes; psychiatric consultations; patients hospitalized; outcomes covid ... See more keywords
Meta-analyses of RELN variants in neuropsychiatric disorders
Sign Up to like & getrecommendations! Published in 2017 at "Behavioural Brain Research"
DOI: 10.1016/j.bbr.2017.05.028
Abstract: &NA; Reelin is a critical extracellular matrix glycoprotein and implicated in neurodevelopment and psychiatric disorders in animal model studies. The genetic polymorphism of RELN has also been reported to be associated with several psychiatric disorders,… read more here.
Keywords: meta analyses; psychiatric disorders; reln variants; neuropsychiatric disorders ... See more keywords
Mitochondrial Etiology of Neuropsychiatric Disorders
Sign Up to like & getrecommendations! Published in 2018 at "Biological Psychiatry"
DOI: 10.1016/j.biopsych.2017.11.018
Abstract: The brain has the highest mitochondrial energy demand of any organ. Therefore, subtle changes in mitochondrial energy production will preferentially affect the brain. Considerable biochemical evidence has accumulated revealing mitochondrial defects associated with neuropsychiatric diseases.… read more here.
Keywords: energy; etiology; dna; etiology neuropsychiatric ... See more keywords