Concepts toward directing human astroplasticity to promote neuroregeneration
Sign Up to like & getrecommendations! Published in 2019 at "Developmental Dynamics"
DOI: 10.1002/dvdy.24655
Abstract: Astrocytes exhibit dynamic and complex reactions to various insults. Recently, investigations into the transitions that occur during cellular specification, differentiation, maturation, and disease responses have provided insights into understanding the mechanisms that underlie these altered… read more here.
Keywords: human astroplasticity; directing human; astroplasticity; toward directing ... See more keywords
Elezanumab, a clinical stage human monoclonal antibody that selectively targets repulsive guidance molecule A to promote neuroregeneration and neuroprotection in neuronal injury and demyelination models
Sign Up to like & getrecommendations! Published in 2021 at "Neurobiology of Disease"
DOI: 10.1016/j.nbd.2021.105492
Abstract: Repulsive guidance molecule A (RGMa) is a potent inhibitor of axonal growth and a regulator of neuronal cell death. It is up-regulated following neuronal injury and accumulates in chronic neurodegenerative diseases. Neutralizing RGMa has the… read more here.
Keywords: antibody; neuroregeneration; rgma; promote ... See more keywords
Dental Mesenchymal Stem Cell Secretome: An Intriguing Approach for Neuroprotection and Neuroregeneration
Sign Up to like & getrecommendations! Published in 2021 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23010456
Abstract: Mesenchymal stem cells (MSCs) are known for their beneficial effects and regenerative potential. In particular, dental-derived MSCs have the advantage of easier accessibility and a non-invasive isolation method. Moreover, thanks to their neural crest origin,… read more here.
Keywords: stem; dental mscs; neuroregeneration; mesenchymal stem ... See more keywords
Brain-derived neurotropic factor and GABAergic transmission in neurodegeneration and neuroregeneration
Sign Up to like & getrecommendations! Published in 2017 at "Neural Regeneration Research"
DOI: 10.4103/1673-5374.217353
Abstract: Neurotoxicity induced by stress, radiation, chemicals, or metabolic diseases, is commonly associated with excitotoxicity, oxidative stress, and neuroinflammation. The pathological process of neurotoxicity induces neuronal death, interrupts synaptic plasticity in the brain, and is similar… read more here.
Keywords: brain derived; transmission; neuroregeneration; derived neurotropic ... See more keywords