Neurotensin in the nucleus accumbens reverses dopamine supersensitivity evoked by antipsychotic treatment
Sign Up to like & getrecommendations! Published in 2017 at "Neuropharmacology"
DOI: 10.1016/j.neuropharm.2017.05.015
Abstract: &NA; Long‐term exposure to antipsychotics like haloperidol can increase sensitivity to dopamine agonist stimulation. This could contribute to treatment failure and increase relapse to psychosis. Chronic antipsychotic treatment elevates neurotensin levels in the nucleus accumbens… read more here.
Keywords: dopamine supersensitivity; treatment; neurotensin; hal ... See more keywords
Neurotensin stimulates the sperm acrosome reaction and reduces percentages of fertilization in vitro
Sign Up to like & getrecommendations! Published in 2019 at "Fertility and Sterility"
DOI: 10.1016/j.xfss.2020.03.001
Abstract: Objective To determine the impact of neurotensin (NTS), a naturally occurring peptide, on the function of human and nonhuman primate sperm. Design Experimental study. Setting University-based research laboratory. Patient(s)/Animal(s) Consenting normozoospermic human donors and cynomolgus… read more here.
Keywords: fertilization; acrosome reaction; neurotensin; sperm acrosome ... See more keywords
Use of Molecular Modeling to Design Selective NTS2 Neurotensin Analogues.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.6b01848
Abstract: Neurotensin exerts potent analgesia by acting at both NTS1 and NTS2 receptors, whereas NTS1 activation also results in other physiological effects such as hypotension and hypothermia. Here, we used molecular modeling approach to design highly… read more here.
Keywords: nts1 nts2; molecular modeling; selective nts2; neurotensin ... See more keywords
Neurotensin and Adverse Cardiovascular Outcomes in Patients Undergoing Percutaneous Coronary Intervention
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cardiovascular Medicine"
DOI: 10.3389/fcvm.2022.782602
Abstract: Background Neurotensin is involved in fatty acid and glucose metabolism and promotes the development of obesity and diabetes. These associations appear to be more pronounced in women. We investigated the association of neurotensin with long-term… read more here.
Keywords: adverse cardiovascular; neurotensin; female patients; log ... See more keywords
Neuromedin U and neurotensin may promote the development of the tumour microenvironment in neuroblastoma
Sign Up to like & getrecommendations! Published in 2021 at "PeerJ"
DOI: 10.7717/peerj.11512
Abstract: Stage 4S neuroblastoma, as defined by the International Neuroblastoma Staging System committee (INSS), is known to regress spontaneously and have a more favourable outcome compared with stage 4 tumours. Comparing the molecular differences between these… read more here.
Keywords: analysis; neuroblastoma; neurotensin; database ... See more keywords