Expression and Purification of a Functional E. coli 13CH3-Methionine-Labeled Thermostable Neurotensin Receptor 1 Variant for Solution NMR Studies.
Sign Up to like & getrecommendations! Published in 2019 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-9121-1_3
Abstract: Escherichia coli (E. coli) is the most widely used expression host for recombinant proteins due to high expression yields and straightforward molecular cloning. Directed evolution of G protein-coupled receptors (GPCRs) has made several of these… read more here.
Keywords: neurotensin receptor; solution nmr; methionine; 13ch3 methionine ... See more keywords
Molecular Dynamics and Docking Studies on Neurotensin Receptor
Sign Up to like & getrecommendations! Published in 2017 at "Biophysical Journal"
DOI: 10.1016/j.bpj.2016.11.1907
Abstract: In recent times, a significant portion of molecular simulation works have been focused on G-protein Coupled Receptors (GPCR). Given the fact that drug discovery paradigm has identified GPCR as important class as target membrane protein,… read more here.
Keywords: neurotensin receptor; dynamics docking; molecular dynamics; docking studies ... See more keywords
Neurotensin 1 receptor in the prelimbic cortex regulates anxiety-like behavior in rats
Sign Up to like & getrecommendations! Published in 2021 at "Progress in Neuro-Psychopharmacology and Biological Psychiatry"
DOI: 10.1016/j.pnpbp.2020.110011
Abstract: The central neurotensin system has been implicated in reward, memory processes, also in the regulation of anxiety. However, the neural substrates where neurotensin acts to regulate anxiety have not been fully identified. The prelimbic region… read more here.
Keywords: neurotensin receptor; cortex; anxiety; anxiety like ... See more keywords
Discovery of b-Arrestin Biased, Orally Bioavailable and CNS Penetrant Neurotensin Receptor 1 (NTR1) Allosteric Modulators.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.9b00340
Abstract: Neurotensin receptor 1 (NTR1) is a G protein coupled receptor that is widely expressed throughout the central nervous sys-tem where it acts as a neuromodulator. Neurotensin receptors have been implicated in a wide variety of… read more here.
Keywords: neurotensin receptor; receptor ntr1; cns; ntr1 allosteric ... See more keywords
Activation Pathways of Neurotensin Receptor 1 Elucidated Using Statistical Machine Learning.
Sign Up to like & getrecommendations! Published in 2022 at "ACS chemical neuroscience"
DOI: 10.1021/acschemneuro.2c00154
Abstract: Neurotensin receptor 1 (NTSR1) is a G-protein coupled receptor (GPCR) that mediates many biological processes through its interaction with the neurotensin (NTS) peptide. The NTSR1 protein is a clinically significant target as it is involved… read more here.
Keywords: machine learning; neurotensin receptor; ntsr1 protein; receptor ... See more keywords
Design, Synthesis, and Biological Evaluation of the First Radio-Metalated Neurotensin Analogue Targeting Neurotensin Receptor 2
Sign Up to like & getrecommendations! Published in 2023 at "ACS Omega"
DOI: 10.1021/acsomega.2c07814
Abstract: Neurotensin receptor 2 (NTS2) is a well-known mediator of central opioid-independent analgesia. Seminal studies have highlighted NTS2 overexpression in a variety of tumors including prostate cancer, pancreas adenocarcinoma, and breast cancer. Herein, we describe the… read more here.
Keywords: jmv; jmv 7488; 111in jmv; 68ga jmv ... See more keywords
Effect of Ligands and Transducers on the Neurotensin Receptor 1 Conformational Ensemble.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.2c00828
Abstract: Using a discrete, intracellular 19F nuclear magnetic resonance (NMR) probe on transmembrane helix 6 of the neurotensin receptor 1 (NTS1), we aim to understand how ligands and transducers modulate the receptor's structural ensemble in a… read more here.
Keywords: neurotensin receptor; ligands transducers; effect ligands; active like ... See more keywords
Protective effect of neurotensin receptor-1 agonist PD 149163 against lipopolysaccharide-induced gut toxicity in mice.
Sign Up to like & getrecommendations! Published in 2021 at "Drug and chemical toxicology"
DOI: 10.1080/01480545.2021.1954698
Abstract: The interaction between neuroendocrine and immune components of the gut maintains the organism's physical and psychological health. Its disruption may reflect in disease conditions such as inflammatory bowel disease (IBD) and mental illness. The lipopolysaccharide… read more here.
Keywords: neurotensin receptor; protective effect; agonist 149163; toxicity ... See more keywords
Virtual screening of a natural compound library at orthosteric and allosteric binding sites of the neurotensin receptor
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Biomolecular Structure and Dynamics"
DOI: 10.1080/07391102.2018.1552200
Abstract: Abstract Molecular dynamics (MD) simulation using the AMBER force field has been performed on the neurotensin (NT) receptor, a class A type G-protein-coupled receptor in its activated conformation co-crystallized with the non-peptide agonists. For structure-based… read more here.
Keywords: compound library; neurotensin receptor; library orthosteric; compound ... See more keywords
Anorexia and fat aversion induced by vertical sleeve gastrectomy is attenuated in neurotensin receptor 1 deficient mice.
Sign Up to like & getrecommendations! Published in 2021 at "Endocrinology"
DOI: 10.1210/endocr/bqab130
Abstract: Neurotensin (NT) is an anorexic gut hormone and neuropeptide that increases in circulation following bariatric surgery in humans and rodents. We sought to determine the contribution of NT to the metabolic efficacy of vertical sleeve… read more here.
Keywords: vertical sleeve; neurotensin receptor; vsg; sleeve gastrectomy ... See more keywords
Association of Neurotensin Receptor 1 Gene Polymorphisms With Defense Mechanisms in Healthy Chinese
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Psychiatry"
DOI: 10.3389/fpsyt.2021.762276
Abstract: Aims: In the central nerve system, neurotensin (NT), and neurotensin receptor 1 (NTR1) modulate the dopamine system. Gene variations in the dopamine system have been demonstrated to influence certain defense mechanisms, but no studies have… read more here.
Keywords: defense; defense mechanisms; gene polymorphisms; neurotensin receptor ... See more keywords