A transient inflammatory response contributes to oxaliplatin neurotoxicity in mice
Sign Up to like & getrecommendations! Published in 2022 at "Annals of Clinical and Translational Neurology"
DOI: 10.1002/acn3.51691
Abstract: Peripheral neuropathy is a relevant dose‐limiting adverse event that can affect up to 90% of oncologic patients with colorectal cancer receiving oxaliplatin treatment. The severity of neurotoxicity often leads to dose reduction or even premature… read more here.
Keywords: inflammatory response; oxaliplatin neurotoxicity; response contributes; neurotoxicity ... See more keywords
Physiological assessment of high glucose neurotoxicity in mouse and rat retinal explants
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Comparative Neurology"
DOI: 10.1002/cne.24805
Abstract: One of the tissues of the central nervous system most affected by diabetes is the retina. Despite a growing understanding of the biochemical processes involved in glucose toxicity, little is known about the physiological consequences… read more here.
Keywords: retinal explants; physiological assessment; high glucose; assessment high ... See more keywords
The Amphibian Short Term Assay (ASTA): Evaluation of a new ecotoxicological method for amphibians using two organophosphate pesticides commonly found in nature. Assessment of behavioral traits.
Sign Up to like & getrecommendations! Published in 2023 at "Environmental toxicology and chemistry"
DOI: 10.1002/etc.5642
Abstract: Neurotoxic pesticides are used worldwide to protect crops from insects, they are recognized to impact nontarget organisms that live in areas surrounded by treated crops. Many biochemical and cell-based solutions have been developed for testing… read more here.
Keywords: impact; amphibian short; term assay; neurotoxicity ... See more keywords
Neurotoxicity of ischemic astrocytes involves STAT3‐mediated metabolic switching and depends on glycogen usage
Sign Up to like & getrecommendations! Published in 2023 at "Glia"
DOI: 10.1002/glia.24357
Abstract: Astrocytic responses are critical for the maintenance of neuronal networks in health and disease. In stroke, reactive astrocytes undergo functional changes potentially contributing to secondary neurodegeneration, but the mechanisms of astrocyte‐mediated neurotoxicity remain elusive. Here,… read more here.
Keywords: ischemic astrocytes; stat3; metabolic switching; glycogen usage ... See more keywords
Hemin provides protection against lead neurotoxicity through heme oxygenase 1/carbon monoxide activation
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Applied Toxicology"
DOI: 10.1002/jat.3646
Abstract: The neurotoxicity of lead (Pb) is well established, and oxidative stress is strongly associated with Pb‐induced neurotoxicity. Heme oxygenase 1 (HO‐1) is an important antioxidative enzyme for protection against oxidative stress in many disease models.… read more here.
Keywords: protection; hemin; neurotoxicity; carbon monoxide ... See more keywords
Research progress on components and mechanisms of neurotoxicity induced by traditional Chinese medicine
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Applied Toxicology"
DOI: 10.1002/jat.4396
Abstract: Over the years, the safety of traditional Chinese medicine (TCM) has received widespread attention, especially the central nervous system‐related adverse reactions. Indeed, the complexity of TCM has limited the widespread application of TCM. The article… read more here.
Keywords: chinese medicine; tcm; neurotoxicity; research progress ... See more keywords
New insights into arsenic, lead, and iron neurotoxicity: Activation of MAPK signaling pathway and oxidative stress.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of biochemical and molecular toxicology"
DOI: 10.1002/jbt.23040
Abstract: Toxic metals cause neurodegeneration via formation of toxic complexes with the cellular compounds and production of highly reactive oxygen species. The present study aimed to investigate the role of mitogen-activated protein kinase (MAPK) signaling pathway… read more here.
Keywords: mapk signaling; iron; lead; signaling pathway ... See more keywords
Comparative assessment of neurotoxicity impacts induced by alkyl tri‐n‐butyl phosphate and aromatic tricresyl phosphate in PC12 cells
Sign Up to like & getrecommendations! Published in 2020 at "Environmental Toxicology"
DOI: 10.1002/tox.22997
Abstract: Organophosphate flame retardants (OPFRs) have become a growing concern due to their potential environmental and health risk. However, limited studies have described the toxicity, particularly neurotoxicity of alkyl and aromatic OPFRs. This study investigated the… read more here.
Keywords: pc12 cells; alkyl tri; neurotoxicity; tri butyl ... See more keywords
Triclosan induces zebrafish neurotoxicity by abnormal expression of miR-219 targeting oligodendrocyte differentiation of central nervous system
Sign Up to like & getrecommendations! Published in 2020 at "Archives of Toxicology"
DOI: 10.1007/s00204-020-02661-1
Abstract: Triclosan (TCS) is ubiquitous in a wide range of personal care and consumer products, and it is acute/chronic exposure may result in several nervous system disorders. Previous studies demonstrated TCS-induced abnormal expression of miRNAs, but… read more here.
Keywords: nervous system; tcs; expression; differentiation ... See more keywords
Neurofilament light chain: a specific serum biomarker of axonal damage severity in rat models of Chemotherapy-Induced Peripheral Neurotoxicity
Sign Up to like & getrecommendations! Published in 2020 at "Archives of Toxicology"
DOI: 10.1007/s00204-020-02755-w
Abstract: Chemotherapy-Induced Peripheral Neurotoxicity (CIPN) is a severe and long-lasting side effect of anticancer therapy, which can severely impair patients’ quality of life. It is a sensory and length-dependent neuropathy, which predominantly affects large myelinated fibers.… read more here.
Keywords: axonal damage; severity; neurotoxicity; peripheral neurotoxicity ... See more keywords
Neurotoxicity of pesticides
Sign Up to like & getrecommendations! Published in 2019 at "Acta Neuropathologica"
DOI: 10.1007/s00401-019-02033-9
Abstract: Pesticides are unique environmental contaminants that are specifically introduced into the environment to control pests, often by killing them. Although pesticide application serves many important purposes, including protection against crop loss and against vector-borne diseases,… read more here.
Keywords: neurotoxicity pesticides; pesticide; neurotoxicity;