A transient inflammatory response contributes to oxaliplatin neurotoxicity in mice
Sign Up to like & getrecommendations! Published in 2022 at "Annals of Clinical and Translational Neurology"
DOI: 10.1002/acn3.51691
Abstract: Peripheral neuropathy is a relevant dose‐limiting adverse event that can affect up to 90% of oncologic patients with colorectal cancer receiving oxaliplatin treatment. The severity of neurotoxicity often leads to dose reduction or even premature… read more here.
Keywords: inflammatory response; oxaliplatin neurotoxicity; response contributes; neurotoxicity ... See more keywords
Neurotoxicity from inordinate valacyclovir dosage in an elderly woman with stage 5 chronic kidney disease
Sign Up to like & getrecommendations! Published in 2025 at "British Journal of Clinical Pharmacology"
DOI: 10.1002/bcp.70138
Abstract: Unadjusted doses of valacyclovir can cause neurotoxicity in patients with chronic kidney disease. There are no well documented reports of valacyclovir or acyclovir toxicity providing pre‐ and postdialysis concentrations of acyclovir in the blood, dialysate… read more here.
Keywords: disease; neurotoxicity; haemodialysis; kidney disease ... See more keywords
Physiological assessment of high glucose neurotoxicity in mouse and rat retinal explants
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Comparative Neurology"
DOI: 10.1002/cne.24805
Abstract: One of the tissues of the central nervous system most affected by diabetes is the retina. Despite a growing understanding of the biochemical processes involved in glucose toxicity, little is known about the physiological consequences… read more here.
Keywords: retinal explants; physiological assessment; high glucose; assessment high ... See more keywords
The Amphibian Short Term Assay (ASTA): Evaluation of a new ecotoxicological method for amphibians using two organophosphate pesticides commonly found in nature. Assessment of behavioral traits.
Sign Up to like & getrecommendations! Published in 2023 at "Environmental toxicology and chemistry"
DOI: 10.1002/etc.5642
Abstract: Neurotoxic pesticides are used worldwide to protect crops from insects, they are recognized to impact nontarget organisms that live in areas surrounded by treated crops. Many biochemical and cell-based solutions have been developed for testing… read more here.
Keywords: impact; amphibian short; term assay; neurotoxicity ... See more keywords
Neurotoxicity of ischemic astrocytes involves STAT3‐mediated metabolic switching and depends on glycogen usage
Sign Up to like & getrecommendations! Published in 2023 at "Glia"
DOI: 10.1002/glia.24357
Abstract: Astrocytic responses are critical for the maintenance of neuronal networks in health and disease. In stroke, reactive astrocytes undergo functional changes potentially contributing to secondary neurodegeneration, but the mechanisms of astrocyte‐mediated neurotoxicity remain elusive. Here,… read more here.
Keywords: ischemic astrocytes; stat3; metabolic switching; glycogen usage ... See more keywords
Hemin provides protection against lead neurotoxicity through heme oxygenase 1/carbon monoxide activation
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Applied Toxicology"
DOI: 10.1002/jat.3646
Abstract: The neurotoxicity of lead (Pb) is well established, and oxidative stress is strongly associated with Pb‐induced neurotoxicity. Heme oxygenase 1 (HO‐1) is an important antioxidative enzyme for protection against oxidative stress in many disease models.… read more here.
Keywords: protection; hemin; neurotoxicity; carbon monoxide ... See more keywords
Research progress on components and mechanisms of neurotoxicity induced by traditional Chinese medicine
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Applied Toxicology"
DOI: 10.1002/jat.4396
Abstract: Over the years, the safety of traditional Chinese medicine (TCM) has received widespread attention, especially the central nervous system‐related adverse reactions. Indeed, the complexity of TCM has limited the widespread application of TCM. The article… read more here.
Keywords: chinese medicine; tcm; neurotoxicity; research progress ... See more keywords
New insights into arsenic, lead, and iron neurotoxicity: Activation of MAPK signaling pathway and oxidative stress.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of biochemical and molecular toxicology"
DOI: 10.1002/jbt.23040
Abstract: Toxic metals cause neurodegeneration via formation of toxic complexes with the cellular compounds and production of highly reactive oxygen species. The present study aimed to investigate the role of mitogen-activated protein kinase (MAPK) signaling pathway… read more here.
Keywords: mapk signaling; iron; lead; signaling pathway ... See more keywords
GRIA1 Alleviates Sevoflurane‐Induced Neurotoxicity by Suppressing Autophagy
Sign Up to like & getrecommendations! Published in 2025 at "Journal of Biochemical and Molecular Toxicology"
DOI: 10.1002/jbt.70281
Abstract: The neurotoxicity caused by inhaled anesthetics has attracted more attention. Sevoflurane (SEV), a common general anesthetic, has a wide range of clinical applications. However, the underlying molecular mechanism of SEV‐induced neurotoxicity is blurry.Cell viability and… read more here.
Keywords: neurotoxicity; suppressing autophagy; neurotoxicity suppressing; cell viability ... See more keywords
Comparative assessment of neurotoxicity impacts induced by alkyl tri‐n‐butyl phosphate and aromatic tricresyl phosphate in PC12 cells
Sign Up to like & getrecommendations! Published in 2020 at "Environmental Toxicology"
DOI: 10.1002/tox.22997
Abstract: Organophosphate flame retardants (OPFRs) have become a growing concern due to their potential environmental and health risk. However, limited studies have described the toxicity, particularly neurotoxicity of alkyl and aromatic OPFRs. This study investigated the… read more here.
Keywords: pc12 cells; alkyl tri; neurotoxicity; tri butyl ... See more keywords
BDNF specifically expressed in hippocampal neurons is involved in methylmercury neurotoxicity resistance
Sign Up to like & getrecommendations! Published in 2024 at "Environmental Toxicology"
DOI: 10.1002/tox.24174
Abstract: Methylmercury (MeHg) causes selective neuronal damage to cerebrocortical neurons (CCNs) in the central nervous system, but not to hippocampal neurons (HiNs), which are highly vulnerable to neurodegenerative diseases. In our previous study using cultured rat… read more here.
Keywords: neurotoxicity; resistance; hippocampal neurons; specifically expressed ... See more keywords