Reprogramming the Cleavage Specificity of Botulinum Neurotoxin Serotype B1.
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DOI: 10.1021/acssynbio.2c00235
Abstract: Proteases with reprogrammed specificity for nonnative substrates are highly desired in synthetic biology and biomedicine. However, generating reprogrammed proteases that are orthogonal and highly specific for a new target has been a major challenge. In… read more here.
Keywords: protease; neurotoxin serotype; specificity; biology ... See more keywords