Neurotoxins subvert the allosteric activation mechanism of SARM1 to induce neuronal loss.
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DOI: 10.1016/j.celrep.2021.109872
Abstract: SARM1 is an inducible TIR-domain NAD+ hydrolase that mediates pathological axon degeneration. SARM1 is activated by an increased ratio of NMN to NAD+, which competes for binding to an allosteric activating site. When NMN binds,… read more here.
Keywords: sarm1; subvert allosteric; allosteric activation; neurotoxins subvert ... See more keywords