On the difficulties of characterizing weak protein interactions that are critical for neurotransmitter release
Sign Up to like & getrecommendations! Published in 2022 at "FEBS Open Bio"
DOI: 10.1002/2211-5463.13473
Abstract: The mechanism of neurotransmitter release has been extensively characterized, showing that vesicle fusion is mediated by the SNARE complex formed by syntaxin‐1, SNAP‐25 and synaptobrevin. This complex is disassembled by N‐ethylmaleimide sensitive factor (NSF) and… read more here.
Keywords: neurotransmitter; weak interactions; neurotransmitter release; protein interactions ... See more keywords
Tonotopic differentiation of presynaptic neurotransmitter‐releasing machinery in the auditory brainstem during the prehearing period and its selective deficits in Fmr1 knockout mice
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Comparative Neurology"
DOI: 10.1002/cne.25406
Abstract: Tonotopic organization is a fundamental feature of the auditory system. In the developing auditory brainstem, the ontogeny and maturation of neurotransmission progress from high to low frequencies along the tonotopic axis. To explore the underlying… read more here.
Keywords: tonotopic differentiation; auditory brainstem; prehearing period; neurotransmitter ... See more keywords
Neurochemical Organization of the Drosophila Brain Visualized by Endogenously Tagged Neurotransmitter Receptors.
Sign Up to like & getrecommendations! Published in 2020 at "Cell reports"
DOI: 10.1016/j.celrep.2019.12.018
Abstract: Neurotransmitters often have multiple receptors that induce distinct responses in receiving cells. Expression and localization of neurotransmitter receptors in individual neurons are therefore critical for understanding the operation of neural circuits. Here we describe a… read more here.
Keywords: organization drosophila; neurotransmitter; neurochemical organization; neurotransmitter receptors ... See more keywords
Nafion-stabilized two-dimensional transition metal carbide (Ti3C2Tx MXene) as a high-performance electrochemical sensor for neurotransmitter
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Industrial and Engineering Chemistry"
DOI: 10.1016/j.jiec.2019.03.061
Abstract: Abstract Herein, we demonstrate the selective sensing of Dopamine (DA), an important neurotransmitter, by using Nafion-stabilized two-dimensional transition metal carbides (Ti3C2Tx MXenes). Ti3C2Tx was deposited on a glassy carbon electrode followed by Nafion coating to… read more here.
Keywords: transition metal; stabilized two; neurotransmitter; two dimensional ... See more keywords
Anatomic resolution of neurotransmitter-specific projections to the VTA reveals diversity of GABAergic inputs
Sign Up to like & getrecommendations! Published in 2020 at "Nature Neuroscience"
DOI: 10.1038/s41593-020-0657-z
Abstract: The ventral tegmental area (VTA) is important for reward processing and motivation. The anatomic organization of neurotransmitter-specific inputs to the VTA remains poorly resolved. In the present study, we mapped the major neurotransmitter projections to… read more here.
Keywords: resolution neurotransmitter; anatomic resolution; gabaergic inputs; projections vta ... See more keywords
Mechanism for neurotransmitter-receptor matching
Sign Up to like & getrecommendations! Published in 2020 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.1916600117
Abstract: Significance Neurotransmitter switching generally involves replacement of an excitatory transmitter with an inhibitory transmitter or vice versa and has been linked to changes in animal behavior. There are corresponding switches in postsynaptic receptors that enable… read more here.
Keywords: mechanism; transmitter; neurotransmitter; expression ... See more keywords
Structure and Gating Dynamics of Na+/Cl– Coupled Neurotransmitter Transporters
Sign Up to like & getrecommendations! Published in 2019 at "Frontiers in Molecular Biosciences"
DOI: 10.3389/fmolb.2019.00080
Abstract: Neurotransmitters released at the neural synapse through vesicle exocytosis are spatiotemporally controlled by the action of neurotransmitter transporters. Integral membrane proteins of the solute carrier 6 (SLC6) family are involved in the sodium and chloride… read more here.
Keywords: neurotransmitter transporters; structure gating; gating dynamics; dynamics coupled ... See more keywords
Neurotransmitter content heterogeneity within an interneuron class shapes inhibitory transmission at a central synapse
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cellular Neuroscience"
DOI: 10.3389/fncel.2022.1060189
Abstract: Neurotransmitter content is deemed the most basic defining criterion for neuronal classes, contrasting with the intercellular heterogeneity of many other molecular and functional features. Here we show, in the adult mouse brain, that neurotransmitter content… read more here.
Keywords: heterogeneity; class; content heterogeneity; neurotransmitter content ... See more keywords
Deciphering of Adult Glioma Vulnerabilities through Expression Pattern Analysis of GABA, Glutamate and Calcium Neurotransmitter Genes
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Personalized Medicine"
DOI: 10.3390/jpm12040633
Abstract: Adult infiltrating gliomas are highly aggressive tumors of the central nervous system with a dismal prognosis despite intensive multimodal therapy (chemotherapy and/or radiotherapy). In this study, we studied the expression, methylation and interacting miRNA profiles… read more here.
Keywords: adult; analysis; glioma; gaba glutamate ... See more keywords