On the difficulties of characterizing weak protein interactions that are critical for neurotransmitter release
Sign Up to like & getrecommendations! Published in 2022 at "FEBS Open Bio"
DOI: 10.1002/2211-5463.13473
Abstract: The mechanism of neurotransmitter release has been extensively characterized, showing that vesicle fusion is mediated by the SNARE complex formed by syntaxin‐1, SNAP‐25 and synaptobrevin. This complex is disassembled by N‐ethylmaleimide sensitive factor (NSF) and… read more here.
Keywords: neurotransmitter; weak interactions; neurotransmitter release; protein interactions ... See more keywords
The Probability of Neurotransmitter Release Governs AMPA Receptor Trafficking via Activity-Dependent Regulation of mGluR1 Surface Expression
Sign Up to like & getrecommendations! Published in 2018 at "Cell Reports"
DOI: 10.1016/j.celrep.2018.12.010
Abstract: A major mechanism contributing to synaptic plasticity involves alterations in the number of AMPA receptors (AMPARs) expressed at synapses. Hippocampal CA1 synapses, where this process has been most extensively studied, are highly heterogeneous with respect… read more here.
Keywords: probability neurotransmitter; mglur1; neurotransmitter release; activity ... See more keywords
Presynaptic mechanisms underlying GABAB-receptor-mediated inhibition of spontaneous neurotransmitter release
Sign Up to like & getrecommendations! Published in 2022 at "Cell reports"
DOI: 10.1016/j.celrep.2021.110255
Abstract: SUMMARY Inhibition of neurotransmitter release by neurotransmitter substances constitutes a fundamental means of neuromodulation. In contrast to well-delineated mechanisms that underlie inhibition of evoked release via suppression of voltage-gated Ca2+ channels, processes that underlie neuromodulatory… read more here.
Keywords: release; inhibition; neurotransmitter release; inhibition spontaneous ... See more keywords
One Cycle Fuels Another: The Energetics of Neurotransmitter Release
Sign Up to like & getrecommendations! Published in 2017 at "Neuron"
DOI: 10.1016/j.neuron.2017.01.024
Abstract: In this issue of Neuron, Ashrafi et al. (2017) show that activity induces translocation of the insulin-regulated glucose transporter GLUT4 to the plasma membrane, where it sustains the ATP production required for synaptic vesicle cycling. However,… read more here.
Keywords: cycle fuels; another energetics; one cycle; fuels another ... See more keywords
The Control of Neuronal Calcium Homeostasis by SNAP-25 and its Impact on Neurotransmitter Release
Sign Up to like & getrecommendations! Published in 2019 at "Neuroscience"
DOI: 10.1016/j.neuroscience.2018.11.009
Abstract: The process of neurotransmitter release is central to the control of cell-to-cell communication in brain. SNAP-25 is a component of the SNARE complex, which, together with syntaxin-1 and synaptobrevin, mediates synaptic vesicle fusion with the… read more here.
Keywords: control; impact; neurotransmitter release; calcium ... See more keywords
Erigeron annuus flower absolute prolongs botulinum neurotoxin A-induced muscle paralysis and inhibits neurotransmitter release-linked responses.
Sign Up to like & getrecommendations! Published in 2022 at "Natural product research"
DOI: 10.1080/14786419.2022.2036147
Abstract: This study aimed to determine the effects of Erigeron annuus (L.) Pers. (EAP) flower absolute (EAPFAb) on neurotransmitter release-blocking events and muscle paralysis induced by botulinum neurotoxin type A (BoNT/A). For this study, EAPFAb was… read more here.
Keywords: neurotransmitter release; erigeron annuus; muscle; muscle paralysis ... See more keywords
Neurotransmitter release cycle-related genes predict the prognosis of lung adenocarcinoma.
Sign Up to like & getrecommendations! Published in 2022 at "Medicine"
DOI: 10.1097/md.0000000000030469
Abstract: Because of the limitations of therapeutic approaches, patients suffering from lung adenocarcinoma (LUAD) have unsatisfactory prognoses. Studies have shown that neurotransmitters participated in tumorigenesis and development. In LUAD, the expression of neurotransmitter release cycle-related genes… read more here.
Keywords: release cycle; neurotransmitter release; prognosis; cycle related ... See more keywords
The role of RIM in neurotransmitter release: promotion of synaptic vesicle docking, priming, and fusion
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Neuroscience"
DOI: 10.3389/fnins.2023.1123561
Abstract: There are many special sites at the end of a synapse called active zones (AZs). Synaptic vesicles (SVs) fuse with presynaptic membranes at these sites, and this fusion is an important step in neurotransmitter release.… read more here.
Keywords: priming fusion; role; neurotransmitter release; docking priming ... See more keywords
Physiological Concentrations of Amyloid Beta Regulate Recycling of Synaptic Vesicles via Alpha7 Acetylcholine Receptor and CDK5/Calcineurin Signaling
Sign Up to like & getrecommendations! Published in 2017 at "Frontiers in Molecular Neuroscience"
DOI: 10.3389/fnmol.2017.00221
Abstract: Despite the central role of amyloid β (Aβ) peptide in the etiopathogenesis of Alzheimer’s disease (AD), its physiological function in healthy brain is still debated. It is well established that elevated levels of Aβ induce… read more here.
Keywords: calcineurin signaling; cdk5 calcineurin; alpha7 acetylcholine; physiological concentrations ... See more keywords
Drunken lipid membranes, not drunken SNARE proteins, promote fusion in a model of neurotransmitter release
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Molecular Neuroscience"
DOI: 10.3389/fnmol.2022.1022756
Abstract: Alcohol affects many neuronal proteins that are upstream or down-stream of synaptic vesicle fusion and neurotransmitter release. Less well studied is alcohol’s effect on the fusion machinery including SNARE proteins and lipid membranes. Using a… read more here.
Keywords: lipid membranes; fusion; neurotransmitter release; snare proteins ... See more keywords
Genetic disorders of neurotransmitter release machinery
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Synaptic Neuroscience"
DOI: 10.3389/fnsyn.2023.1148957
Abstract: Synaptic neurotransmitter release is an evolutionarily conserved process that mediates rapid information transfer between neurons as well as several peripheral tissues. Release of neurotransmitters are ensured by successive events such as synaptic vesicle docking and… read more here.
Keywords: release machinery; neurotransmitter release; genetic disorders; disorders neurotransmitter ... See more keywords