Translational Studies in the Complex Role of Neurotransmitter Systems in Anxiety and Anxiety Disorders.
Sign Up to like & getrecommendations! Published in 2020 at "Advances in experimental medicine and biology"
DOI: 10.1007/978-981-32-9705-0_8
Abstract: Discovery of innovative anxiolytics is severely hampering. Existing anxiolytics are developed decades ago and are still the therapeutics of choice. Moreover, lack of new drug targets forecasts a severe jeopardy in the future treatment of… read more here.
Keywords: complex role; translational studies; anxiety; studies complex ... See more keywords
Alterations and interactions of subcortical modulatory systems in Alzheimer's disease.
Sign Up to like & getrecommendations! Published in 2021 at "Progress in brain research"
DOI: 10.1016/bs.pbr.2020.07.016
Abstract: The pathogenesis of Alzheimer's disease (AD) is not fully understood. Here we summarize current knowledge on the involvement of the serotonergic, noradrenergic, dopaminergic, cholinergic, and opioid systems in AD, emphasizing the importance of interactions between… read more here.
Keywords: subcortical modulatory; alzheimer disease; neurotransmitter systems; modulatory systems ... See more keywords
A new generation of antidepressants: an update on the pharmaceutical pipeline for novel and rapid-acting therapeutics in mood disorders based on glutamate/GABA neurotransmitter systems.
Sign Up to like & getrecommendations! Published in 2019 at "Drug discovery today"
DOI: 10.1016/j.drudis.2018.11.007
Abstract: Mood disorders represent the largest cause of disability worldwide. The monoaminergic deficiency hypothesis, which has dominated the conceptual framework for researching the pathophysiology of mood disorders and the development of novel treatment strategies, cannot fully… read more here.
Keywords: new generation; mood disorders; mood; neurotransmitter systems ... See more keywords
Involvement of classical neurotransmitter systems in memory reconsolidation: Focus on destabilization
Sign Up to like & getrecommendations! Published in 2018 at "Neurobiology of Learning and Memory"
DOI: 10.1016/j.nlm.2018.11.001
Abstract: &NA; When consolidated long‐term memories are reactivated they can destabilize, rendering the memory labile and vulnerable to modification. This period of lability is followed by reconsolidation, a process that restabilizes the memory trace. Reactivation‐induced memory… read more here.
Keywords: memory destabilization; destabilization; neurotransmitter systems; reconsolidation ... See more keywords
Deficient neurotransmitter systems and synaptic function in frontotemporal lobar degeneration—Insights into disease mechanisms and current therapeutic approaches
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DOI: 10.1038/s41380-021-01384-8
Abstract: Frontotemporal lobar degeneration (FTLD) comprises a heterogenous group of fatal neurodegenerative diseases and, to date, no validated diagnostic or prognostic biomarkers or effective disease-modifying therapies exist for the different clinical or genetic subtypes of FTLD.… read more here.
Keywords: deficient neurotransmitter; neurotransmitter systems; frontotemporal lobar; lobar degeneration ... See more keywords
O7.6. META-ANALYSIS OF EFFICACY OF COGNITIVE ENHANCERS FOR PATIENTS WITH SCHIZOPHRENIA-SPECTRUM DISORDERS
Sign Up to like & getrecommendations! Published in 2018 at "Schizophrenia Bulletin"
DOI: 10.1093/schbul/sby015.235
Abstract: Abstract Background Cognitive impairment is a core feature of schizophrenia, which is predictive for functional outcomes and should therefore be one of the main treatment targets. Pharmacological enhancement of cognition has been a main field… read more here.
Keywords: system; cognitive enhancers; analysis; neurotransmitter systems ... See more keywords