Potential role of NGF, BDNF, and their receptors in oligodendrocytes differentiation from neural stem cell: An in vitro study
Sign Up to like & getrecommendations! Published in 2020 at "Cell Biology International"
DOI: 10.1002/cbin.11500
Abstract: Neural stem cells (NSCs) or neuronal progenitor cells are cells capable of differentiating into oligodendrocytes, myelin‐forming cells that have the potential of remyelination. Brain‐derived neurotrophic factor (BDNF) and nerve growth factor (NGF) are two neurotrophic… read more here.
Keywords: nsc differentiation; neurotrophic factors; role; neural stem ... See more keywords
Modulation of neurotrophic factors in the treatment of dementia, stroke and TBI: Effects of Cerebrolysin.
Sign Up to like & getrecommendations! Published in 2023 at "Medicinal research reviews"
DOI: 10.1002/med.21960
Abstract: Neurotrophic factors (NTFs) are involved in the pathophysiology of neurological disorders such as dementia, stroke and traumatic brain injury (TBI), and constitute molecular targets of high interest for the therapy of these pathologies. In this… read more here.
Keywords: neurotrophic factors; dementia stroke; stroke tbi; treatment ... See more keywords
Neurotrophic factors and neuroplasticity pathways in the pathophysiology and treatment of depression
Sign Up to like & getrecommendations! Published in 2018 at "Psychopharmacology"
DOI: 10.1007/s00213-018-4950-4
Abstract: Depression is a major health problem with a high prevalence and a heavy socioeconomic burden in western societies. It is associated with atrophy and impaired functioning of cortico-limbic regions involved in mood and emotion regulation.… read more here.
Keywords: depression; pathophysiology treatment; treatment; treatment depression ... See more keywords
Role of Neurotrophic Factors BDNF and GDNF in Nervous System Adaptation to the Influence of Ischemic Factors
Sign Up to like & getrecommendations! Published in 2019 at "Bulletin of Experimental Biology and Medicine"
DOI: 10.1007/s10517-019-04574-1
Abstract: We developed a complex in vitro model of ischemic damage. Analysis of hippocampal cell viability in primary cultures after modeling of various stress factors revealed the features of action of the main pathological factors of… read more here.
Keywords: role neurotrophic; gdnf nervous; bdnf gdnf; nervous system ... See more keywords
Parkinson’s Disease–Associated Changes in the Expression of Neurotrophic Factors and their Receptors upon Neuronal Differentiation of Human Induced Pluripotent Stem Cells
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Molecular Neuroscience"
DOI: 10.1007/s12031-019-01450-5
Abstract: Parkinson’s disease (PD) is a neurodegenerative pathology resulting from the degeneration of dopaminergic (DA) neurons in the substantia nigra (SN). Neurotrophic factors (NTFs) and their receptors are key regulators of the survival, differentiation, and development… read more here.
Keywords: human induced; differentiation; pluripotent stem; induced pluripotent ... See more keywords
Glucose Can Epigenetically Alter the Gene Expression of Neurotrophic Factors in the Murine Brain Cells
Sign Up to like & getrecommendations! Published in 2017 at "Molecular Neurobiology"
DOI: 10.1007/s12035-017-0578-3
Abstract: Glucose is believed to improve the memory in both human and mice, but the detailed insights were mostly elusive. In this study, we focused on two major neurotrophic factors, brain-derived neurotrophic factor (BDNF) and fibroblast… read more here.
Keywords: glucose epigenetically; brain; expression; neurotrophic factors ... See more keywords
Omics-based exploration and functional validation of neurotrophic factors and histamine as therapeutic targets in ALS
Sign Up to like & getrecommendations! Published in 2020 at "Ageing Research Reviews"
DOI: 10.1016/j.arr.2020.101121
Abstract: A plethora of genetic and molecular mechanisms have been implicated in the pathophysiology of the heterogeneous and multifactorial amyotrophic lateral sclerosis (ALS) disease, and hence the conventional "one target-one drug" paradigm has failed so far… read more here.
Keywords: omics based; therapeutic targets; based exploration; factors histamine ... See more keywords
Conduits harnessing spatially controlled cell-secreted neurotrophic factors improve peripheral nerve regeneration.
Sign Up to like & getrecommendations! Published in 2019 at "Biomaterials"
DOI: 10.1016/j.biomaterials.2019.01.038
Abstract: An essential structure in nerve regeneration within engineered conduits is the "nerve bridge" initiated by centrally migrating Schwann cells in response to chemokine gradients. Introducing exogenous cells secreting neurotrophic factors aims to augment this repair… read more here.
Keywords: cell; peripheral nerve; nerve; neurotrophic factors ... See more keywords
The role of neurotrophic factors in manic-, anxious- and depressive-like behaviors induced by amphetamine sensitization: Implications to the animal model of bipolar disorder.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of affective disorders"
DOI: 10.1016/j.jad.2018.10.370
Abstract: BACKGROUND Bipolar disorder (BD) and substance use disorders share common symptoms, such as behavioral sensitization. Amphetamine-induced behavioral sensitization can serve as an animal model of BD. Neurotrophic factors have an important role in BD pathophysiology.… read more here.
Keywords: animal model; like behaviors; bipolar disorder; neurotrophic factors ... See more keywords
Expression of Neurotrophic Factors in Human Dentin and Their Regulation of Trigeminal Neurite Outgrowth
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Endodontics"
DOI: 10.1016/j.joen.2018.12.011
Abstract: Introduction: Neurotrophic factors play a significant role in the innervation of the pulp‐dentin complex during and after organogenesis. There have been numerous bioactive molecules identified in the dentin extracellular matrix; however, the expression of neurotrophic… read more here.
Keywords: dentin; neurite outgrowth; expression neurotrophic; human dentin ... See more keywords
Unconventional neurotrophic factors CDNF and MANF: Structure, physiological functions and therapeutic potential
Sign Up to like & getrecommendations! Published in 2017 at "Neurobiology of Disease"
DOI: 10.1016/j.nbd.2016.07.009
Abstract: Cerebral dopamine neurotrophic factor (CDNF) and mesencephalic astrocyte-derived neurotrophic factor (MANF) promote the survival of midbrain dopaminergic neurons which degenerate in Parkinson's disease (PD). However, CDNF and MANF are structurally and functionally clearly distinct from… read more here.
Keywords: cdnf manf; physiological functions; unconventional neurotrophic; factors cdnf ... See more keywords