Understanding the Pathogenesis of Neurotrophic Keratitis: The Role of Corneal Nerves
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DOI: 10.1002/jcp.25623
Abstract: Neurotrophic keratitis (NK) is a rare degenerative disease of the cornea caused by trigeminal nerve damage, which leads to loss of corneal sensitivity, corneal epithelium breakdown, and poor healing. Though extremely uncommon, NK is increasingly… read more here.
Keywords: neurotrophic keratitis; corneal; role corneal; corneal nerves ... See more keywords
Cenegermin: A Review in Neurotrophic Keratitis
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DOI: 10.1007/s40265-020-01289-w
Abstract: Cenegermin (Oxervate™), an ophthalmic solution containing 20 µg/mL of recombinant human nerve growth factor (rhNGF), is the first drug to be approved for the treatment of neurotrophic keratitis (NK; also referred to as neurotrophic keratopathy). In… read more here.
Keywords: neurotrophic keratitis; cenegermin review; treatment; corneal healing ... See more keywords
Phase I Trial of Recombinant Human Nerve Growth Factor for Neurotrophic Keratitis.
Sign Up to like & getrecommendations! Published in 2018 at "Ophthalmology"
DOI: 10.1016/j.ophtha.2018.03.004
Abstract: Neurotrophic keratitis/keratopathy (NK), a rare degenerative corneal disease, lacks effective pharmacologic therapies.1 Because NK pathology involves trigeminal nerve damage and loss of corneal innervation, nerve growth factor (NGF) is surmised to promote healing of NK.2… read more here.
Keywords: neurotrophic keratitis; recombinant human; phase; nerve growth ... See more keywords
Use of Nicergoline as Adjunctive Treatment of Neurotrophic Keratitis in Routine Clinical Practice: A Case Series.
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DOI: 10.1080/09273948.2021.1976214
Abstract: PURPOSE To describe the effectiveness and safety of nicergoline in patients with epithelial corneal defect or corneal ulcer due to neurotrophic keratitis (NK). METHODS A prospective case series review was performed in 14 patients with… read more here.
Keywords: neurotrophic keratitis; clinical practice; treatment; adjunctive treatment ... See more keywords