Identification and application of p75 neurotrophin receptor-expressing human trabecular meshwork progenitor cells.
Sign Up to like & getrecommendations! Published in 2019 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2019.04.178
Abstract: The trabecular meshwork (TM) is a tissue that originates from the neural crest via the periocular mesenchyme and plays a role in draining water and maintaining intraocular pressure (IOP). Damage to the TM is associated… read more here.
Keywords: neurotrophin receptor; trabecular meshwork; progenitor cells; p75 ... See more keywords
BNN-20, a synthetic microneurotrophin, strongly protects dopaminergic neurons in the “weaver” mouse, a genetic model of dopamine-denervation, acting through the TrkB neurotrophin receptor
Sign Up to like & getrecommendations! Published in 2017 at "Neuropharmacology"
DOI: 10.1016/j.neuropharm.2017.04.043
Abstract: Neurotrophic factors are among the most promising treatments aiming at slowing or stopping and even reversing Parkinson's disease (PD). However, in most cases, they cannot readily cross the human blood-brain-barrier (BBB). Herein, we propose as… read more here.
Keywords: bnn; neurotrophin receptor; bnn synthetic; trkb neurotrophin ... See more keywords
The p75 neurotrophin receptor enhances HIF‐dependent signaling in glioma
Sign Up to like & getrecommendations! Published in 2018 at "Experimental Cell Research"
DOI: 10.1016/j.yexcr.2018.08.002
Abstract: ABSTRACT Tumor hypoxia is associated with several features of aggressive glioma growth, including migration, invasion, and stemness. Most of the cellular adaptation to hypoxia is mediated by the hypoxia‐inducible factors HIF‐1&agr; and HIF‐2&agr;, but regulation… read more here.
Keywords: neurotrophin receptor; glioma; hif dependent; hif agr ... See more keywords
Role of p75 neurotrophin receptor in neuronal autophagy in intracerebral hemorrhage in rats through the mTOR signaling pathway
Sign Up to like & getrecommendations! Published in 2020 at "Cell Cycle"
DOI: 10.1080/15384101.2019.1711318
Abstract: ABSTRACT Rupture of weakened blood vessels could lead to severe intracerebral hemorrhage (ICH) and brain injuries. This study was designed to explore the roles of p75 neurotrophin receptor (p75NTR) in neuronal autophagy in ICH rats.… read more here.
Keywords: neurotrophin receptor; intracerebral hemorrhage; mtor signaling; brain ... See more keywords
The p75 neurotrophin receptor regulates cranial irradiation-induced hippocampus-dependent cognitive dysfunction
Sign Up to like & getrecommendations! Published in 2017 at "Oncotarget"
DOI: 10.18632/oncotarget.16492
Abstract: Cognitive deficits, characterized by progressive problems with hippocampus-dependent learning, memory and spatial processing, are the most serious complication of cranial irradiation. However, the underlying mechanisms remain obscure. The p75 neurotrophin receptor (p75NTR) is involved in… read more here.
Keywords: neurotrophin receptor; irradiation; hippocampus dependent; irradiation induced ... See more keywords
Reversal of Cognitive Impairment in gp120 Transgenic Mice by the Removal of the p75 Neurotrophin Receptor
Sign Up to like & getrecommendations! Published in 2019 at "Frontiers in Cellular Neuroscience"
DOI: 10.3389/fncel.2019.00398
Abstract: Activation of the p75 neurotrophin receptor (p75NTR), by the proneurotrophin brain-derived neurotrophic factor (proBDNF), triggers loss of synapses and promotes neuronal death. These pathological features are also caused by the human immunodeficiency virus-1 (HIV) envelope… read more here.
Keywords: neurotrophin receptor; p75ntr; gp120; mice ... See more keywords
Modulation of Small RNA Signatures in Schwann-Cell-Derived Extracellular Vesicles by the p75 Neurotrophin Receptor and Sortilin
Sign Up to like & getrecommendations! Published in 2020 at "Biomedicines"
DOI: 10.3390/biomedicines8110450
Abstract: Schwann cells (SCs) are the main glial cells of the peripheral nervous system (PNS) and are known to be involved in various pathophysiological processes, such as diabetic neuropathy and nerve regeneration, through neurotrophin signaling. Such… read more here.
Keywords: neurotrophin receptor; receptor sortilin; sortilin; p75 neurotrophin ... See more keywords
Analysis of the Expression of Neurotrophins and Their Receptors in Adult Zebrafish Kidney
Sign Up to like & getrecommendations! Published in 2022 at "Veterinary Sciences"
DOI: 10.3390/vetsci9060296
Abstract: Neurotrophins and their receptors are involved in the development and maintenance of neuronal populations. Different reports have shown that all neurotrophin/receptor pathways can also play a role in several non-neuronal tissues in vertebrates, including the… read more here.
Keywords: adult zebrafish; kidney; neurotrophins receptors; analysis expression ... See more keywords
Towards a comprehensive understanding of p75 neurotrophin receptor functions and interactions in the brain
Sign Up to like & getrecommendations! Published in 2022 at "Neural Regeneration Research"
DOI: 10.4103/1673-5374.314291
Abstract: The role of neurotrophins in neuronal plasticity has recently become a strong focus in neuroregeneration research field to elucidate the biological mechanisms by which these molecules modulate synapses, modify the response to injury, and alter… read more here.
Keywords: neurotrophin receptor; towards comprehensive; p75 neurotrophin; role ... See more keywords